Title: Effect of abnormal glucose metabolism on severity of coronary artery disease and short-term outcome in patients with acute coronary syndrome
Abstract: Objective:To investigate the relationship between abnormal glucose metabolism and severity of coronary artery disease and short-term outcome in patients with acute coronary syndrome(ACS).Methods:A total of 450 consecutive patients with ACS underwent coronary angiography were included.The severity of coronary artery lesions was graded using Gensini score system.Among 450 patients,140 patients had normal plasma glucose level(Control group),90 patients had impaired fasting glucose(IFG group),95 patients had impaired glucose tolerance(IGT group),and 125 patients had diabetes mellitus(DM group).One-month event rate was recorded.Results:Gensini scores were significantly higher in IGT and DM groups than in control group(63.63±29.43 and 65.63±28.41 vs.47.76±26.54,P0.01,respectively).There was no significant statistical significance in Gensini scores between control group and IFG group(50.34±27.43).Two hour postprandial plasma glucose level was weakly related to Gensini scores(R=0.367,P=0.046).The rates of clinical events(34.3%vs.60.8% and 64.2%)(all P0.01) and all-cause death(6.43%vs.15.2% and 15.78%)(all P0.05) were significantly higher in DM and IGT groups than in control group,but there was no significant difference between IFG and control groups.Conclusion:In ACS patients,those with DM or impaired glucose tolerance were associated with more severe coronary artery disease and poor short-term prognosis.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot