Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3105503666', 'doi': 'https://doi.org/10.1101/682260', 'title': 'Phosphorylated Lamin A/C in the nuclear interior binds active enhancers associated with abnormal transcription in progeria', 'display_name': 'Phosphorylated Lamin A/C in the nuclear interior binds active enhancers associated with abnormal transcription in progeria', 'publication_year': 2019, 'publication_date': '2019-06-26', 'ids': {'openalex': 'https://openalex.org/W3105503666', 'doi': 'https://doi.org/10.1101/682260', 'mag': '3105503666'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/682260', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2019/12/18/682260.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.biorxiv.org/content/biorxiv/early/2019/12/18/682260.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5004218423', 'display_name': 'Kohta Ikegami', 'orcid': 'https://orcid.org/0000-0002-0405-1193'}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Kohta Ikegami', 'raw_affiliation_strings': ['Departments of Human Genetics, The University of Chicago, Chicago, Illinois, USA', 'Departments of Pediatrics, The University of Chicago, Chicago, Illinois, USA'], 'affiliations': [{'raw_affiliation_string': 'Departments of Human Genetics, The University of Chicago, Chicago, Illinois, USA', 'institution_ids': ['https://openalex.org/I40347166']}, {'raw_affiliation_string': 'Departments of Pediatrics, The University of Chicago, Chicago, Illinois, USA', 'institution_ids': ['https://openalex.org/I40347166']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012138144', 'display_name': 'Stefano Secchia', 'orcid': 'https://orcid.org/0000-0003-1000-8543'}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}, {'id': 'https://openalex.org/I187531555', 'display_name': 'Lund University', 'ror': 'https://ror.org/012a77v79', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I187531555']}], 'countries': ['SE', 'US'], 'is_corresponding': False, 'raw_author_name': 'Stefano Secchia', 'raw_affiliation_strings': ['Department of Biology, Lund University, Lund, Sweden', 'Departments of Human Genetics, The University of Chicago, Chicago, Illinois, USA'], 'affiliations': [{'raw_affiliation_string': 'Departments of Human Genetics, The University of Chicago, Chicago, Illinois, USA', 'institution_ids': ['https://openalex.org/I40347166']}, {'raw_affiliation_string': 'Department of Biology, Lund University, Lund, Sweden', 'institution_ids': ['https://openalex.org/I187531555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031889212', 'display_name': 'Omar Almakki', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Omar Almakki', 'raw_affiliation_strings': ['Departments of Pediatrics, The University of Chicago, Chicago, Illinois, USA'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pediatrics, The University of Chicago, Chicago, Illinois, USA', 'institution_ids': ['https://openalex.org/I40347166']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001045048', 'display_name': 'Jason D. Lieb', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jason D. Lieb', 'raw_affiliation_strings': ['Departments of Human Genetics, The University of Chicago, Chicago, Illinois, USA'], 'affiliations': [{'raw_affiliation_string': 'Departments of Human Genetics, The University of Chicago, Chicago, Illinois, USA', 'institution_ids': ['https://openalex.org/I40347166']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029187572', 'display_name': 'Ivan P. Moskowitz', 'orcid': 'https://orcid.org/0000-0003-0014-4963'}, 'institutions': [{'id': 'https://openalex.org/I40347166', 'display_name': 'University of Chicago', 'ror': 'https://ror.org/024mw5h28', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I40347166']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ivan P. Moskowitz', 'raw_affiliation_strings': ['Departments of Human Genetics, The University of Chicago, Chicago, Illinois, USA', 'Departments of Pathology, The University of Chicago, Chicago, Illinois, USA', 'Departments of Pediatrics, The University of Chicago, Chicago, Illinois, USA'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pathology, The University of Chicago, Chicago, Illinois, USA', 'institution_ids': ['https://openalex.org/I40347166']}, {'raw_affiliation_string': 'Departments of Pediatrics, The University of Chicago, Chicago, Illinois, USA', 'institution_ids': ['https://openalex.org/I40347166']}, {'raw_affiliation_string': 'Departments of Human Genetics, The University of Chicago, Chicago, Illinois, USA', 'institution_ids': ['https://openalex.org/I40347166']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5004218423'], 'corresponding_institution_ids': ['https://openalex.org/I40347166'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.712752, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 69, 'max': 74}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11841', 'display_name': 'Nuclear Structure and Function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11841', 'display_name': 'Nuclear Structure and Function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10222', 'display_name': 'Genomics and Chromatin Dynamics', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lmna', 'display_name': 'LMNA', 'score': 0.9895005}, {'id': 'https://openalex.org/keywords/progeria', 'display_name': 'Progeria', 'score': 0.9766896}, {'id': 'https://openalex.org/keywords/nuclear-lamina', 'display_name': 'Nuclear lamina', 'score': 0.74134916}, {'id': 'https://openalex.org/keywords/premature-aging', 'display_name': 'Premature aging', 'score': 0.4958721}], 'concepts': [{'id': 'https://openalex.org/C179093185', 'wikidata': 'https://www.wikidata.org/wiki/Q424506', 'display_name': 'Lamin', 'level': 3, 'score': 0.9920256}, {'id': 'https://openalex.org/C2780654407', 'wikidata': 'https://www.wikidata.org/wiki/Q4253573', 'display_name': 'LMNA', 'level': 4, 'score': 0.9895005}, {'id': 'https://openalex.org/C2778465436', 'wikidata': 'https://www.wikidata.org/wiki/Q213098', 'display_name': 'Progeria', 'level': 3, 'score': 0.9766896}, {'id': 'https://openalex.org/C94912109', 'wikidata': 'https://www.wikidata.org/wiki/Q687194', 'display_name': 'Nuclear lamina', 'level': 5, 'score': 0.74134916}, {'id': 'https://openalex.org/C111936080', 'wikidata': 'https://www.wikidata.org/wiki/Q913367', 'display_name': 'Enhancer', 'level': 4, 'score': 0.6809255}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.64781237}, {'id': 'https://openalex.org/C2909947164', 'wikidata': 'https://www.wikidata.org/wiki/Q6139748', 'display_name': 'Premature aging', 'level': 2, 'score': 0.4958721}, {'id': 'https://openalex.org/C103435993', 'wikidata': 'https://www.wikidata.org/wiki/Q837783', 'display_name': 'Heterochromatin', 'level': 4, 'score': 0.46917823}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.4656288}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.4607578}, {'id': 'https://openalex.org/C83640560', 'wikidata': 'https://www.wikidata.org/wiki/Q180951', 'display_name': 'Chromatin', 'level': 3, 'score': 0.42655554}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.41817266}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.37236857}, {'id': 'https://openalex.org/C29512474', 'wikidata': 'https://www.wikidata.org/wiki/Q16860021', 'display_name': 'Nuclear protein', 'level': 4, 'score': 0.3596235}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.33539253}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/682260', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2019/12/18/682260.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.devcel.2020.02.011', 'pdf_url': None, 'source': None, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/682260', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2019/12/18/682260.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.41, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 94, 'referenced_works': ['https://openalex.org/W1498363663', 'https://openalex.org/W1510449384', 'https://openalex.org/W1526450413', 'https://openalex.org/W1528109689', 'https://openalex.org/W1560616913', 'https://openalex.org/W1574658543', 'https://openalex.org/W1891037876', 'https://openalex.org/W1955474383', 'https://openalex.org/W1964551999', 'https://openalex.org/W1969085991', 'https://openalex.org/W1985092753', 'https://openalex.org/W1988510960', 'https://openalex.org/W1992713810', 'https://openalex.org/W1992900610', 'https://openalex.org/W2001614140', 'https://openalex.org/W2003250511', 'https://openalex.org/W2004087257', 'https://openalex.org/W2008900071', 'https://openalex.org/W2017985097', 'https://openalex.org/W2020520526', 'https://openalex.org/W2026863186', 'https://openalex.org/W2030637965', 'https://openalex.org/W2031211461', 'https://openalex.org/W2032858454', 'https://openalex.org/W2035593347', 'https://openalex.org/W2036410975', 'https://openalex.org/W2038774969', 'https://openalex.org/W2044267903', 'https://openalex.org/W2052011655', 'https://openalex.org/W2054352668', 'https://openalex.org/W2054793128', 'https://openalex.org/W2056074681', 'https://openalex.org/W2057025275', 'https://openalex.org/W2057341073', 'https://openalex.org/W2065634301', 'https://openalex.org/W2068972095', 'https://openalex.org/W2073460054', 'https://openalex.org/W2075168676', 'https://openalex.org/W2076154138', 'https://openalex.org/W2083032264', 'https://openalex.org/W2085110456', 'https://openalex.org/W2087768937', 'https://openalex.org/W2088969742', 'https://openalex.org/W2095668554', 'https://openalex.org/W2101083045', 'https://openalex.org/W2102619694', 'https://openalex.org/W2103777723', 'https://openalex.org/W2104140002', 'https://openalex.org/W2107404798', 'https://openalex.org/W2107665951', 'https://openalex.org/W2108757615', 'https://openalex.org/W2109196816', 'https://openalex.org/W2112124900', 'https://openalex.org/W2114757437', 'https://openalex.org/W2115235864', 'https://openalex.org/W2117289097', 'https://openalex.org/W2117719819', 'https://openalex.org/W2120865735', 'https://openalex.org/W2127365302', 'https://openalex.org/W2127394968', 'https://openalex.org/W2127708563', 'https://openalex.org/W2128353741', 'https://openalex.org/W2129185248', 'https://openalex.org/W2133779787', 'https://openalex.org/W2135717026', 'https://openalex.org/W2136482074', 'https://openalex.org/W2140729960', 'https://openalex.org/W2142014283', 'https://openalex.org/W2144737712', 'https://openalex.org/W2144890804', 'https://openalex.org/W2148032724', 'https://openalex.org/W2148357788', 'https://openalex.org/W2151755793', 'https://openalex.org/W2157952888', 'https://openalex.org/W2170314963', 'https://openalex.org/W2170551349', 'https://openalex.org/W2171808845', 'https://openalex.org/W2179438025', 'https://openalex.org/W2191641478', 'https://openalex.org/W2254635737', 'https://openalex.org/W2314179564', 'https://openalex.org/W2414684615', 'https://openalex.org/W2510536171', 'https://openalex.org/W2537679995', 'https://openalex.org/W2616198309', 'https://openalex.org/W2765547660', 'https://openalex.org/W2767749844', 'https://openalex.org/W2792203963', 'https://openalex.org/W2905232298', 'https://openalex.org/W2917187119', 'https://openalex.org/W2928665623', 'https://openalex.org/W2939263494', 'https://openalex.org/W4211059758', 'https://openalex.org/W4232264930'], 'related_works': ['https://openalex.org/W4221022264', 'https://openalex.org/W4206098026', 'https://openalex.org/W3176419864', 'https://openalex.org/W2317718274', 'https://openalex.org/W2255523009', 'https://openalex.org/W2119526996', 'https://openalex.org/W2066816830', 'https://openalex.org/W2052034221', 'https://openalex.org/W1554973796', 'https://openalex.org/W1484768737'], 'abstract_inverted_index': {'ABSTRACT': [0], 'LMNA': [1, 19, 178], 'encodes': [2], 'nuclear': [3, 14, 156, 189], 'lamin': [4], 'A/C': [5, 40, 59, 146, 169, 184, 194, 215], 'that': [6, 37, 144], 'tethers': [7], 'lamina-associated': [8, 200], 'heterochromatin': [9], 'domains': [10], '(LADs)': [11], 'to': [12, 45], 'the': [13, 24, 31, 46, 49, 55, 76, 155, 160, 188, 209], 'periphery.': [15], 'Point': [16], 'mutations': [17, 179], 'in': [18, 51, 97, 125, 139, 154, 187, 217], 'cause': [20], 'degenerative': [21], 'disorders': [22, 175], 'including': [23, 130, 180], 'premature': [25], 'aging': [26], 'disorder': [27], 'Hutchinson-Gilford': [28], 'progeria,': [29], 'but': [30], 'mechanisms': [32], 'are': [33, 206], 'unknown.': [34], 'We': [35], 'report': [36], 'Ser22-phosphorylated': [38], 'Lamin': [39, 145, 168], '(pS22-Lamin': [41], 'A/C)': [42], 'was': [43], 'localized': [44], 'interior': [47, 190], 'of': [48, 65, 85, 128, 159, 167, 221], 'nucleus': [50], 'human': [52], 'fibroblasts': [53], 'throughout': [54, 191], 'cell': [56], 'cycle.': [57], 'pS22-Lamin': [58, 86, 93, 103, 183, 193, 202, 214], 'interacted': [60], 'with': [61, 196], 'a': [62, 83, 171], 'specific': [63], 'subset': [64, 84], 'putative': [66], 'active': [67, 197], 'enhancers,': [68, 198], 'not': [69, 199], 'LADs,': [70], 'primarily': [71], 'at': [72], 'locations': [73], 'co-bound': [74, 207], 'by': [75, 150, 177, 208], 'transcriptional': [77, 210], 'activator': [78, 211], 'c-Jun.': [79, 212], 'In': [80], 'progeria-patient': [81], 'fibroblasts,': [82], 'A/C-binding': [87, 94, 104], 'sites': [88, 95, 105, 205], 'were': [89, 137], 'lost': [90], 'whereas': [91], 'new': [92, 102, 121], 'emerged': [96], 'normally': [98], 'quiescent': [99], 'loci.': [100], 'These': [101, 141], 'displayed': [106], 'increased': [107, 114], 'histone': [108], 'acetylation': [109], 'and': [110, 135], 'c-Jun': [111], 'binding,': [112], 'implying': [113], 'enhancer': [115, 152], 'activity.': [116], 'The': [117], 'genes': [118], 'near': [119], 'these': [120], 'binding': [122, 153, 204, 216], 'sites,': [123], 'implicated': [124], 'clinical': [126], 'components': [127], 'progeria': [129, 218], 'carotid': [131], 'artery': [132], 'diseases,': [133], 'hypertension,': [134], 'cardiomegaly,': [136], 'upregulated': [138], 'progeria.': [140, 181], 'results': [142], 'suggest': [143], 'regulates': [147], 'gene': [148, 161], 'expression': [149], 'direct': [151], 'interior.': [157], 'Disruption': [158], 'regulatory': [162], 'rather': [163], 'than': [164], 'LAD': [165], 'function': [166], 'presents': [170], 'novel': [172], 'mechanism': [173], 'for': [174], 'caused': [176], 'HIGHLIGHTS': [182], 'is': [185], 'present': [186], 'interphase.': [192], 'associates': [195], 'domains.': [201], 'A/C-genomic': [203], 'New': [213], 'accompanies': [219], 'upregulation': [220], 'disease-related': [222], 'genes.': [223]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3105503666', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-17T23:14:03.398050', 'created_date': '2020-11-23'}