Publication Information

{'id': 'https://openalex.org/W2255523009', 'doi': 'https://doi.org/10.1007/s00418-016-1411-1', 'title': 'Molecular insights into the premature aging disease progeria', 'display_name': 'Molecular insights into the premature aging disease progeria', 'publication_year': 2016, 'publication_date': '2016-02-04', 'ids': {'openalex': 'https://openalex.org/W2255523009', 'doi': 'https://doi.org/10.1007/s00418-016-1411-1', 'mag': '2255523009', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26847180', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4796323'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00418-016-1411-1', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007%2Fs00418-016-1411-1.pdf', 'source': {'id': 'https://openalex.org/S78725770', 'display_name': 'Histochemistry and Cell Biology', 'issn_l': '0948-6143', 'issn': ['0948-6143', '1432-119X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://link.springer.com/content/pdf/10.1007%2Fs00418-016-1411-1.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5041094279', 'display_name': 'Sandra Vidak', 'orcid': 'https://orcid.org/0000-0001-7579-8545'}, 'institutions': [{'id': 'https://openalex.org/I2802916955', 'display_name': 'Max Perutz Labs', 'ror': 'https://ror.org/05cz70a34', 'country_code': 'AT', 'type': 'facility', 'lineage': ['https://openalex.org/I2802916955']}, {'id': 'https://openalex.org/I4210142901', 'display_name': 'Vienna Biocenter', 'ror': 'https://ror.org/04khwmr87', 'country_code': 'AT', 'type': 'other', 'lineage': ['https://openalex.org/I4210142901']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Sandra Vidak', 'raw_affiliation_strings': ['Max F. Perutz Laboratories (MFPL), Department of Medical Biochemistry, Vienna Biocenter (VBC), Medical University Vienna, Dr. Bohr-Gasse 9/3, 1030, Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': 'Max F. Perutz Laboratories (MFPL), Department of Medical Biochemistry, Vienna Biocenter (VBC), Medical University Vienna, Dr. Bohr-Gasse 9/3, 1030, Vienna, Austria', 'institution_ids': ['https://openalex.org/I2802916955', 'https://openalex.org/I4210142901']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5081263278', 'display_name': 'Roland Foisner', 'orcid': 'https://orcid.org/0000-0003-4734-4647'}, 'institutions': [{'id': 'https://openalex.org/I2802916955', 'display_name': 'Max Perutz Labs', 'ror': 'https://ror.org/05cz70a34', 'country_code': 'AT', 'type': 'facility', 'lineage': ['https://openalex.org/I2802916955']}, {'id': 'https://openalex.org/I4210142901', 'display_name': 'Vienna Biocenter', 'ror': 'https://ror.org/04khwmr87', 'country_code': 'AT', 'type': 'other', 'lineage': ['https://openalex.org/I4210142901']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Roland Foisner', 'raw_affiliation_strings': ['Max F. Perutz Laboratories (MFPL), Department of Medical Biochemistry, Vienna Biocenter (VBC), Medical University Vienna, Dr. Bohr-Gasse 9/3, 1030, Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': 'Max F. Perutz Laboratories (MFPL), Department of Medical Biochemistry, Vienna Biocenter (VBC), Medical University Vienna, Dr. Bohr-Gasse 9/3, 1030, Vienna, Austria', 'institution_ids': ['https://openalex.org/I2802916955', 'https://openalex.org/I4210142901']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3190, 'currency': 'EUR', 'value_usd': 4190, 'provenance': 'doaj'}, 'apc_paid': {'value': 3190, 'currency': 'EUR', 'value_usd': 4190, 'provenance': 'doaj'}, 'fwci': 2.086, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 100, 'citation_normalized_percentile': {'value': 0.999737, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '145', 'issue': '4', 'first_page': '401', 'last_page': '417'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11841', 'display_name': 'Nuclear Structure and Function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11841', 'display_name': 'Nuclear Structure and Function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9874, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lmna', 'display_name': 'LMNA', 'score': 0.9763547}, {'id': 'https://openalex.org/keywords/progeria', 'display_name': 'Progeria', 'score': 0.9565552}, {'id': 'https://openalex.org/keywords/nuclear-lamina', 'display_name': 'Nuclear lamina', 'score': 0.8724972}, {'id': 'https://openalex.org/keywords/premature-aging', 'display_name': 'Premature aging', 'score': 0.8027241}], 'concepts': [{'id': 'https://openalex.org/C2780654407', 'wikidata': 'https://www.wikidata.org/wiki/Q4253573', 'display_name': 'LMNA', 'level': 4, 'score': 0.9763547}, {'id': 'https://openalex.org/C2778465436', 'wikidata': 'https://www.wikidata.org/wiki/Q213098', 'display_name': 'Progeria', 'level': 3, 'score': 0.9565552}, {'id': 'https://openalex.org/C179093185', 'wikidata': 'https://www.wikidata.org/wiki/Q424506', 'display_name': 'Lamin', 'level': 3, 'score': 0.9536425}, {'id': 'https://openalex.org/C94912109', 'wikidata': 'https://www.wikidata.org/wiki/Q687194', 'display_name': 'Nuclear lamina', 'level': 5, 'score': 0.8724972}, {'id': 'https://openalex.org/C2909947164', 'wikidata': 'https://www.wikidata.org/wiki/Q6139748', 'display_name': 'Premature aging', 'level': 2, 'score': 0.8027241}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6984126}, {'id': 'https://openalex.org/C83640560', 'wikidata': 'https://www.wikidata.org/wiki/Q180951', 'display_name': 'Chromatin', 'level': 3, 'score': 0.60940295}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.6030507}, {'id': 'https://openalex.org/C78383274', 'wikidata': 'https://www.wikidata.org/wiki/Q421987', 'display_name': 'Intermediate filament', 'level': 4, 'score': 0.42163742}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.41247678}, {'id': 'https://openalex.org/C29512474', 'wikidata': 'https://www.wikidata.org/wiki/Q16860021', 'display_name': 'Nuclear protein', 'level': 4, 'score': 0.21906883}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.17516148}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.1710704}, {'id': 'https://openalex.org/C142669718', 'wikidata': 'https://www.wikidata.org/wiki/Q154626', 'display_name': 'Cytoskeleton', 'level': 3, 'score': 0.11184302}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.102223635}, {'id': 'https://openalex.org/C2780723820', 'wikidata': 'https://www.wikidata.org/wiki/Q1934178', 'display_name': 'Nucleus', 'level': 2, 'score': 0.0828588}], 'mesh': [{'descriptor_ui': 'D019588', 'descriptor_name': 'Aging, Premature', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011371', 'descriptor_name': 'Progeria', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016922', 'descriptor_name': 'Cellular Senescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034904', 'descriptor_name': 'Lamin Type A', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00418-016-1411-1', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007%2Fs00418-016-1411-1.pdf', 'source': {'id': 'https://openalex.org/S78725770', 'display_name': 'Histochemistry and Cell Biology', 'issn_l': '0948-6143', 'issn': ['0948-6143', '1432-119X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4796323', 'pdf_url': 'https://europepmc.org/articles/pmc4796323?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4796323', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26847180', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00418-016-1411-1', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007%2Fs00418-016-1411-1.pdf', 'source': {'id': 'https://openalex.org/S78725770', 'display_name': 'Histochemistry and Cell Biology', 'issn_l': '0948-6143', 'issn': ['0948-6143', '1432-119X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.81, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320307050', 'funder_display_name': 'Progeria Research Foundation', 'award_id': 'PRF2011-37'}, {'funder': 'https://openalex.org/F4320321181', 'funder_display_name': 'Austrian Science Fund', 'award_id': 'DK W1220'}, {'funder': 'https://openalex.org/F4320321181', 'funder_display_name': 'Austrian Science Fund', 'award_id': 'P26492-B20'}], 'datasets': [], 'versions': [], 'referenced_works_count': 183, 'referenced_works': ['https://openalex.org/W1224195541', 'https://openalex.org/W126188432', 'https://openalex.org/W1273675900', 'https://openalex.org/W1493263872', 'https://openalex.org/W1526450413', 'https://openalex.org/W1528109689', 'https://openalex.org/W1534551308', 'https://openalex.org/W1605422985', 'https://openalex.org/W1885920885', 'https://openalex.org/W188824856', 'https://openalex.org/W1906831630', 'https://openalex.org/W1914644234', 'https://openalex.org/W1964551999', 'https://openalex.org/W1967187334', 'https://openalex.org/W1967412255', 'https://openalex.org/W1969371055', 'https://openalex.org/W1970338621', 'https://openalex.org/W1970891016', 'https://openalex.org/W1973685666', 'https://openalex.org/W1974449792', 'https://openalex.org/W1974862758', 'https://openalex.org/W1978992677', 'https://openalex.org/W1980878904', 'https://openalex.org/W1982602899', 'https://openalex.org/W1982998217', 'https://openalex.org/W1983837160', 'https://openalex.org/W1984340155', 'https://openalex.org/W1985936786', 'https://openalex.org/W1985981012', 'https://openalex.org/W1988354925', 'https://openalex.org/W1991965612', 'https://openalex.org/W1992900610', 'https://openalex.org/W1995740614', 'https://openalex.org/W2000970155', 'https://openalex.org/W2001971523', 'https://openalex.org/W2002569327', 'https://openalex.org/W2002636911', 'https://openalex.org/W2003250511', 'https://openalex.org/W2004629460', 'https://openalex.org/W2004790291', 'https://openalex.org/W2009306385', 'https://openalex.org/W2009709618', 'https://openalex.org/W2010335932', 'https://openalex.org/W2010583480', 'https://openalex.org/W2016268789', 'https://openalex.org/W2016619116', 'https://openalex.org/W2016826534', 'https://openalex.org/W2017142557', 'https://openalex.org/W2017870541', 'https://openalex.org/W2022633326', 'https://openalex.org/W2023186182', 'https://openalex.org/W2023314817', 'https://openalex.org/W2024065774', 'https://openalex.org/W2025109362', 'https://openalex.org/W2027272551', 'https://openalex.org/W2029005510', 'https://openalex.org/W2029040415', 'https://openalex.org/W2029492933', 'https://openalex.org/W2029517875', 'https://openalex.org/W2031738820', 'https://openalex.org/W2033175421', 'https://openalex.org/W2033272080', 'https://openalex.org/W2036460961', 'https://openalex.org/W2036973053', 'https://openalex.org/W2038028886', 'https://openalex.org/W2040320236', 'https://openalex.org/W2040810212', 'https://openalex.org/W2041599232', 'https://openalex.org/W2042237470', 'https://openalex.org/W2042307569', 'https://openalex.org/W2042660580', 'https://openalex.org/W2044897807', 'https://openalex.org/W2045856411', 'https://openalex.org/W2046650956', 'https://openalex.org/W2048445712', 'https://openalex.org/W2050838528', 'https://openalex.org/W2052011655', 'https://openalex.org/W2053206914', 'https://openalex.org/W2054632418', 'https://openalex.org/W2055539528', 'https://openalex.org/W2055873350', 'https://openalex.org/W2057025275', 'https://openalex.org/W2060814375', 'https://openalex.org/W2062203555', 'https://openalex.org/W2063084036', 'https://openalex.org/W2066442023', 'https://openalex.org/W2068343781', 'https://openalex.org/W2068654281', 'https://openalex.org/W2071748613', 'https://openalex.org/W2071870365', 'https://openalex.org/W2072810104', 'https://openalex.org/W2073224213', 'https://openalex.org/W2076624979', 'https://openalex.org/W2079643856', 'https://openalex.org/W2081344756', 'https://openalex.org/W2081914422', 'https://openalex.org/W2086864266', 'https://openalex.org/W2088381487', 'https://openalex.org/W2092476887', 'https://openalex.org/W2096131870', 'https://openalex.org/W2096354772', 'https://openalex.org/W2096905898', 'https://openalex.org/W2098596985', 'https://openalex.org/W2099194160', 'https://openalex.org/W2100268116', 'https://openalex.org/W2101083045', 'https://openalex.org/W2101410699', 'https://openalex.org/W2106789608', 'https://openalex.org/W2108757615', 'https://openalex.org/W2109196816', 'https://openalex.org/W2109995938', 'https://openalex.org/W2111175126', 'https://openalex.org/W2111819985', 'https://openalex.org/W2112299930', 'https://openalex.org/W2114597129', 'https://openalex.org/W2114905428', 'https://openalex.org/W2115038593', 'https://openalex.org/W2116350182', 'https://openalex.org/W2116435487', 'https://openalex.org/W2117719819', 'https://openalex.org/W2119526996', 'https://openalex.org/W2120902817', 'https://openalex.org/W2121358816', 'https://openalex.org/W2122860817', 'https://openalex.org/W2122983246', 'https://openalex.org/W2123028629', 'https://openalex.org/W2125121177', 'https://openalex.org/W2126525177', 'https://openalex.org/W2127365302', 'https://openalex.org/W2127659175', 'https://openalex.org/W2127680780', 'https://openalex.org/W2127708563', 'https://openalex.org/W2127804300', 'https://openalex.org/W2127910803', 'https://openalex.org/W2128353741', 'https://openalex.org/W2128803395', 'https://openalex.org/W2130024105', 'https://openalex.org/W2130452417', 'https://openalex.org/W2131116166', 'https://openalex.org/W2131593425', 'https://openalex.org/W2134267224', 'https://openalex.org/W2136237360', 'https://openalex.org/W2137006062', 'https://openalex.org/W2137864335', 'https://openalex.org/W2138394251', 'https://openalex.org/W2138409013', 'https://openalex.org/W2140844163', 'https://openalex.org/W2140998213', 'https://openalex.org/W2141153332', 'https://openalex.org/W2141334538', 'https://openalex.org/W2142014283', 'https://openalex.org/W2142780571', 'https://openalex.org/W2143185290', 'https://openalex.org/W2143717744', 'https://openalex.org/W2143742350', 'https://openalex.org/W2145514796', 'https://openalex.org/W2145778293', 'https://openalex.org/W2147298899', 'https://openalex.org/W2148221837', 'https://openalex.org/W2148618665', 'https://openalex.org/W2149619603', 'https://openalex.org/W2150619381', 'https://openalex.org/W2151331444', 'https://openalex.org/W2153605484', 'https://openalex.org/W2154155687', 'https://openalex.org/W2154950275', 'https://openalex.org/W2155725433', 'https://openalex.org/W2160591443', 'https://openalex.org/W2163819508', 'https://openalex.org/W2165644047', 'https://openalex.org/W2166403801', 'https://openalex.org/W2167519058', 'https://openalex.org/W2169608475', 'https://openalex.org/W2170314963', 'https://openalex.org/W2172254982', 'https://openalex.org/W2174626854', 'https://openalex.org/W2261310019', 'https://openalex.org/W2317009399', 'https://openalex.org/W2439636367', 'https://openalex.org/W2476542314', 'https://openalex.org/W4211059758', 'https://openalex.org/W590165251', 'https://openalex.org/W961024891'], 'related_works': ['https://openalex.org/W4221022264', 'https://openalex.org/W4206098026', 'https://openalex.org/W3176419864', 'https://openalex.org/W2317718274', 'https://openalex.org/W2255523009', 'https://openalex.org/W2119526996', 'https://openalex.org/W2066816830', 'https://openalex.org/W2052034221', 'https://openalex.org/W1554973796', 'https://openalex.org/W1484768737'], 'abstract_inverted_index': {'Hutchinson–Gilford': [0], 'progeria': [1], 'syndrome': [2], '(HGPS)': [3], 'is': [4, 36, 53, 76, 86], 'an': [5], 'extremely': [6], 'rare': [7], 'premature': [8, 186], 'aging': [9, 17], 'disease': [10, 154, 202], 'presenting': [11], 'many': [12, 146], 'features': [13], 'resembling': [14], 'the': [15, 23, 41, 45, 58, 65, 73, 90, 116, 132, 138, 201], 'normal': [16], 'process.': [18], 'HGPS': [19, 35, 111], 'patients': [20], 'die': [21], 'before': [22], 'age': [24], 'of': [25, 57, 72, 115, 141, 177], '20': [26], 'years': [27], 'due': [28], 'to': [29, 38, 110, 113, 174, 200], 'cardiovascular': [30], 'problems': [31], 'and': [32, 75, 81, 101, 119, 136, 164, 168, 185, 196, 212], 'heart': [33], 'failure.': [34], 'linked': [37, 109], 'mutations': [39], 'in': [40, 78, 89, 98, 159, 170, 210], 'LMNA': [42, 107, 117], 'gene': [43, 102], 'encoding': [44], 'intermediate': [46], 'filament': [47], 'protein': [48, 125], 'lamin': [49, 123], 'A.': [50], 'Lamin': [51, 84], 'A': [52, 85, 124], 'a': [54, 61, 121], 'major': [55], 'component': [56], 'nuclear': [59, 66, 91, 134], 'lamina,': [60], 'scaffold': [62], 'structure': [63], 'at': [64], 'envelope': [67], 'that': [68, 128], 'defines': [69], 'mechanochemical': [70], 'properties': [71, 140], 'nucleus': [74], 'involved': [77], 'chromatin': [79, 162], 'organization': [80, 163], 'epigenetic': [82], 'regulation.': [83, 103], 'also': [87], 'present': [88], 'interior': [92], 'where': [93], 'it': [94], 'fulfills': [95], 'lamina-independent': [96], 'functions': [97], 'cell': [99, 187], 'signaling': [100, 171], 'The': [104], 'most': [105], 'common': [106], 'mutation': [108], 'leads': [112], 'mis-splicing': [114], 'mRNA': [118], 'produces': [120], 'mutant': [122], 'called': [126], 'progerin': [127], 'tightly': [129], 'associates': [130], 'with': [131], 'inner': [133], 'membrane': [135], 'affects': [137], 'dynamic': [139], 'lamins.': [142], 'Progerin': [143], 'expression': [144], 'impairs': [145], 'important': [147], 'cellular': [148], 'processes': [149], 'providing': [150], 'insight': [151], 'into': [152], 'potential': [153, 198], 'mechanisms.': [155], 'These': [156], 'include': [157], 'changes': [158, 169], 'mechanosignaling,': [160], 'altered': [161], 'impaired': [165, 175], 'genome': [166], 'stability,': [167], 'pathways,': [172], 'leading': [173], 'regulation': [176], 'adult': [178], 'stem': [179], 'cells,': [180], 'defective': [181], 'extracellular': [182], 'matrix': [183], 'production': [184], 'senescence.': [188], 'In': [189], 'this': [190], 'review,': [191], 'we': [192], 'discuss': [193], 'these': [194], 'pathways': [195], 'their': [197], 'contribution': [199], 'pathologies': [203], 'as': [204, 206], 'well': [205], 'therapeutic': [207], 'approaches': [208], 'used': [209], 'preclinical': [211], 'clinical': [213], 'tests.': [214]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2255523009', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 19}, {'year': 2018, 'cited_by_count': 17}, {'year': 2017, 'cited_by_count': 17}, {'year': 2016, 'cited_by_count': 5}], 'updated_date': '2024-12-19T03:09:55.426153', 'created_date': '2016-06-24'}