Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2317718274', 'doi': 'https://doi.org/10.2741/216', 'title': 'A-type lamins and Hutchinson-Gilford progeria syndrome: pathogenesis and therapy', 'display_name': 'A-type lamins and Hutchinson-Gilford progeria syndrome: pathogenesis and therapy', 'publication_year': 2011, 'publication_date': '2011-01-01', 'ids': {'openalex': 'https://openalex.org/W2317718274', 'doi': 'https://doi.org/10.2741/216', 'mag': '2317718274', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21622261'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2741/216', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210222084', 'display_name': 'Frontiers in Bioscience-Scholar', 'issn_l': '1945-0516', 'issn': ['1945-0516', '1944-7906', '1945-0524'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310322753', 'host_organization_name': 'IMR Press', 'host_organization_lineage': ['https://openalex.org/P4310322753'], 'host_organization_lineage_names': ['IMR Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://repisalud.isciii.es/bitstream/20.500.12105/7658/1/A-typeLaminsHutchinson-Gilford_2011.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029953673', 'display_name': 'M. Gonzalez Jose', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210148788', 'display_name': 'Instituto de Biomedicina de Valencia', 'ror': 'https://ror.org/05pq8vh42', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210148788']}, {'id': 'https://openalex.org/I134820265', 'display_name': 'Consejo Superior de Investigaciones Científicas', 'ror': 'https://ror.org/02gfc7t72', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I134820265']}, {'id': 'https://openalex.org/I4210147680', 'display_name': 'Centro de Investigaciones Biológicas Margarita Salas', 'ror': 'https://ror.org/04advdf21', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210147680']}, {'id': 'https://openalex.org/I2809107791', 'display_name': 'Spanish National Centre for Cardiovascular Research', 'ror': 'https://ror.org/02qs1a797', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I2809107791', 'https://openalex.org/I4210098440']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Jose, M. Gonzalez', 'raw_affiliation_strings': ['Almagro 3 28029 Madrid, Spain.', 'Chemical and Physical Biology Department, Centro de Investigaciones Biológicas, CSIC, 28040-Madrid, Spain.', 'Laboratory of Molecular and Genetic Cardiovascular Pathophysiology, Department of Epidemiology, Atherothrombosis and Cardiovascular Imaging, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernandez Almagro 3. 28029 Madrid, Spain.', 'Laboratory of Vascular Biology, Department of Molecular and Cellular Pathology and Therapy, Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas (CSIC), 46010-Valencia, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Vascular Biology, Department of Molecular and Cellular Pathology and Therapy, Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Científicas (CSIC), 46010-Valencia, Spain.', 'institution_ids': ['https://openalex.org/I4210148788', 'https://openalex.org/I134820265']}, {'raw_affiliation_string': 'Chemical and Physical Biology Department, Centro de Investigaciones Biológicas, CSIC, 28040-Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210147680']}, {'raw_affiliation_string': 'Almagro 3 28029 Madrid, Spain.', 'institution_ids': []}, {'raw_affiliation_string': 'Laboratory of Molecular and Genetic Cardiovascular Pathophysiology, Department of Epidemiology, Atherothrombosis and Cardiovascular Imaging, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernandez Almagro 3. 28029 Madrid, Spain.', 'institution_ids': ['https://openalex.org/I2809107791']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5029953673'], 'corresponding_institution_ids': ['https://openalex.org/I4210148788', 'https://openalex.org/I134820265', 'https://openalex.org/I4210147680', 'https://openalex.org/I2809107791'], 'apc_list': {'value': 500, 'currency': 'USD', 'value_usd': 500, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.617, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 43, 'citation_normalized_percentile': {'value': 0.666468, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': 'S3', 'issue': '1', 'first_page': '1133', 'last_page': '1133'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11841', 'display_name': 'Nuclear Structure and Function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11841', 'display_name': 'Nuclear Structure and Function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11559', 'display_name': 'Retinoids in leukemia and cellular processes', 'score': 0.99, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/progeria', 'display_name': 'Progeria', 'score': 0.98873454}, {'id': 'https://openalex.org/keywords/lmna', 'display_name': 'LMNA', 'score': 0.98399407}, {'id': 'https://openalex.org/keywords/nuclear-lamina', 'display_name': 'Nuclear lamina', 'score': 0.80998373}, {'id': 'https://openalex.org/keywords/pathogenesis', 'display_name': 'Pathogenesis', 'score': 0.5816375}, {'id': 'https://openalex.org/keywords/premature-aging', 'display_name': 'Premature aging', 'score': 0.54905957}], 'concepts': [{'id': 'https://openalex.org/C2778465436', 'wikidata': 'https://www.wikidata.org/wiki/Q213098', 'display_name': 'Progeria', 'level': 3, 'score': 0.98873454}, {'id': 'https://openalex.org/C2780654407', 'wikidata': 'https://www.wikidata.org/wiki/Q4253573', 'display_name': 'LMNA', 'level': 4, 'score': 0.98399407}, {'id': 'https://openalex.org/C179093185', 'wikidata': 'https://www.wikidata.org/wiki/Q424506', 'display_name': 'Lamin', 'level': 3, 'score': 0.9821625}, {'id': 'https://openalex.org/C94912109', 'wikidata': 'https://www.wikidata.org/wiki/Q687194', 'display_name': 'Nuclear lamina', 'level': 5, 'score': 0.80998373}, {'id': 'https://openalex.org/C2780942790', 'wikidata': 'https://www.wikidata.org/wiki/Q372016', 'display_name': 'Pathogenesis', 'level': 2, 'score': 0.5816375}, {'id': 'https://openalex.org/C2909947164', 'wikidata': 'https://www.wikidata.org/wiki/Q6139748', 'display_name': 'Premature aging', 'level': 2, 'score': 0.54905957}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.53844124}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.43991935}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3412122}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.32064077}, {'id': 'https://openalex.org/C29512474', 'wikidata': 'https://www.wikidata.org/wiki/Q16860021', 'display_name': 'Nuclear protein', 'level': 4, 'score': 0.24051702}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.21565562}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.19721198}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.07202369}], 'mesh': [{'descriptor_ui': 'D003286', 'descriptor_name': 'Contracture', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015316', 'descriptor_name': 'Genetic Therapy', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D034904', 'descriptor_name': 'Lamin Type A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D034881', 'descriptor_name': 'Nuclear Lamina', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011371', 'descriptor_name': 'Progeria', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011371', 'descriptor_name': 'Progeria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011498', 'descriptor_name': 'Protein Precursors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012868', 'descriptor_name': 'Skin Abnormalities', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003286', 'descriptor_name': 'Contracture', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051231', 'descriptor_name': 'Farnesyltranstransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051231', 'descriptor_name': 'Farnesyltranstransferase', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D015316', 'descriptor_name': 'Genetic Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034904', 'descriptor_name': 'Lamin Type A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034904', 'descriptor_name': 'Lamin Type A', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034881', 'descriptor_name': 'Nuclear Lamina', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011371', 'descriptor_name': 'Progeria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011371', 'descriptor_name': 'Progeria', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D011498', 'descriptor_name': 'Protein Precursors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012868', 'descriptor_name': 'Skin Abnormalities', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2741/216', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210222084', 'display_name': 'Frontiers in Bioscience-Scholar', 'issn_l': '1945-0516', 'issn': ['1945-0516', '1944-7906', '1945-0524'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310322753', 'host_organization_name': 'IMR Press', 'host_organization_lineage': ['https://openalex.org/P4310322753'], 'host_organization_lineage_names': ['IMR Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/20.500.12105/7658', 'pdf_url': 'https://repisalud.isciii.es/bitstream/20.500.12105/7658/1/A-typeLaminsHutchinson-Gilford_2011.pdf', 'source': {'id': 'https://openalex.org/S4306402641', 'display_name': 'LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4383465926', 'host_organization_name': 'LA Referencia', 'host_organization_lineage': ['https://openalex.org/I4383465926'], 'host_organization_lineage_names': ['LA Referencia'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21622261', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/20.500.12105/7658', 'pdf_url': 'https://repisalud.isciii.es/bitstream/20.500.12105/7658/1/A-typeLaminsHutchinson-Gilford_2011.pdf', 'source': {'id': 'https://openalex.org/S4306402641', 'display_name': 'LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4383465926', 'host_organization_name': 'LA Referencia', 'host_organization_lineage': ['https://openalex.org/I4383465926'], 'host_organization_lineage_names': ['LA Referencia'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.85, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 145, 'referenced_works': ['https://openalex.org/W1482103235', 'https://openalex.org/W1501180970', 'https://openalex.org/W1563194997', 'https://openalex.org/W1569061529', 'https://openalex.org/W1602375218', 'https://openalex.org/W1665551917', 'https://openalex.org/W1679229316', 'https://openalex.org/W1873492158', 'https://openalex.org/W1964551999', 'https://openalex.org/W1964666836', 'https://openalex.org/W1965824330', 'https://openalex.org/W1970338621', 'https://openalex.org/W1971934332', 'https://openalex.org/W1973728232', 'https://openalex.org/W1976506286', 'https://openalex.org/W1978705807', 'https://openalex.org/W1979927283', 'https://openalex.org/W1984004619', 'https://openalex.org/W1985680803', 'https://openalex.org/W1985981012', 'https://openalex.org/W1986734527', 'https://openalex.org/W1995554502', 'https://openalex.org/W1998666034', 'https://openalex.org/W2001387494', 'https://openalex.org/W2002569327', 'https://openalex.org/W2004613898', 'https://openalex.org/W20054081', 'https://openalex.org/W2008620234', 'https://openalex.org/W2009306385', 'https://openalex.org/W2011506478', 'https://openalex.org/W2012181460', 'https://openalex.org/W2012550276', 'https://openalex.org/W2013167944', 'https://openalex.org/W2013661745', 'https://openalex.org/W2015878902', 'https://openalex.org/W2021128415', 'https://openalex.org/W2022572059', 'https://openalex.org/W2023314817', 'https://openalex.org/W2023353768', 'https://openalex.org/W2023649556', 'https://openalex.org/W2028518802', 'https://openalex.org/W2029492933', 'https://openalex.org/W2031920140', 'https://openalex.org/W2032600498', 'https://openalex.org/W2036379096', 'https://openalex.org/W2036501682', 'https://openalex.org/W2036973053', 'https://openalex.org/W2041767552', 'https://openalex.org/W2042660580', 'https://openalex.org/W2043485308', 'https://openalex.org/W2043934275', 'https://openalex.org/W2044865509', 'https://openalex.org/W2048445712', 'https://openalex.org/W2048839498', 'https://openalex.org/W2049207174', 'https://openalex.org/W2050838528', 'https://openalex.org/W2052011655', 'https://openalex.org/W2053206914', 'https://openalex.org/W2054059225', 'https://openalex.org/W2054632418', 'https://openalex.org/W2054765453', 'https://openalex.org/W2057329292', 'https://openalex.org/W2059800438', 'https://openalex.org/W2062028126', 'https://openalex.org/W2062459861', 'https://openalex.org/W2062490010', 'https://openalex.org/W2063313804', 'https://openalex.org/W2066095189', 'https://openalex.org/W2066501944', 'https://openalex.org/W2072245143', 'https://openalex.org/W2072810104', 'https://openalex.org/W2074997168', 'https://openalex.org/W2076643325', 'https://openalex.org/W2077027914', 'https://openalex.org/W2079643856', 'https://openalex.org/W2080671298', 'https://openalex.org/W2083296702', 'https://openalex.org/W2083530785', 'https://openalex.org/W2084981478', 'https://openalex.org/W2093266075', 'https://openalex.org/W2094303671', 'https://openalex.org/W2094806530', 'https://openalex.org/W2096131870', 'https://openalex.org/W2099705607', 'https://openalex.org/W2100922770', 'https://openalex.org/W2101410699', 'https://openalex.org/W2101520990', 'https://openalex.org/W2102766053', 'https://openalex.org/W2102803890', 'https://openalex.org/W2103286704', 'https://openalex.org/W2103679095', 'https://openalex.org/W2108757615', 'https://openalex.org/W2109196816', 'https://openalex.org/W2109987315', 'https://openalex.org/W2111175126', 'https://openalex.org/W2111819985', 'https://openalex.org/W2115739136', 'https://openalex.org/W2118898403', 'https://openalex.org/W2122860817', 'https://openalex.org/W2123704670', 'https://openalex.org/W2123779962', 'https://openalex.org/W2125314433', 'https://openalex.org/W2127365302', 'https://openalex.org/W2127708563', 'https://openalex.org/W2127804300', 'https://openalex.org/W2129446626', 'https://openalex.org/W2135871043', 'https://openalex.org/W2136237360', 'https://openalex.org/W2136490523', 'https://openalex.org/W2136979747', 'https://openalex.org/W2137564725', 'https://openalex.org/W2137864335', 'https://openalex.org/W2140558481', 'https://openalex.org/W2141153332', 'https://openalex.org/W2141334538', 'https://openalex.org/W2142265454', 'https://openalex.org/W2143185290', 'https://openalex.org/W2143571321', 'https://openalex.org/W2143963878', 'https://openalex.org/W2145079083', 'https://openalex.org/W2145283260', 'https://openalex.org/W2145860725', 'https://openalex.org/W2148221837', 'https://openalex.org/W2148279593', 'https://openalex.org/W2148618665', 'https://openalex.org/W2149777340', 'https://openalex.org/W2150619381', 'https://openalex.org/W2151331444', 'https://openalex.org/W2151755793', 'https://openalex.org/W2153462989', 'https://openalex.org/W2154950275', 'https://openalex.org/W2157443558', 'https://openalex.org/W2157478214', 'https://openalex.org/W2160553642', 'https://openalex.org/W2164175250', 'https://openalex.org/W2164893149', 'https://openalex.org/W2165974961', 'https://openalex.org/W2166205445', 'https://openalex.org/W2168438125', 'https://openalex.org/W2169643859', 'https://openalex.org/W2410447900', 'https://openalex.org/W4234803938', 'https://openalex.org/W4240995072', 'https://openalex.org/W4252391910', 'https://openalex.org/W4300704428'], 'related_works': ['https://openalex.org/W4221022264', 'https://openalex.org/W3176419864', 'https://openalex.org/W2255523009', 'https://openalex.org/W2119526996', 'https://openalex.org/W2066816830', 'https://openalex.org/W2052034221', 'https://openalex.org/W2003768435', 'https://openalex.org/W1981901085', 'https://openalex.org/W1554973796', 'https://openalex.org/W1484768737'], 'abstract_inverted_index': {'Lamin': [0], 'A': [1, 114], 'and': [2, 37, 83, 96, 144, 151], 'lamin': [3, 113], 'C': [4], '(A-type': [5], 'lamins,': [6], 'both': [7], 'encoded': [8], 'by': [9], 'the': [10, 17, 54, 57, 67, 132, 137, 142, 145, 155, 159], 'LMNA': [11], 'gene)': [12], 'are': [13], 'major': [14], 'components': [15], 'of': [16, 41, 46, 56, 69, 76, 103, 112, 141, 157, 161, 171], 'mammalian': [18], 'nuclear': [19, 35], 'lamina,': [20], 'a': [21, 28, 43, 50, 62], 'complex': [22], 'proteinaceous': [23], 'structure': [24, 36], 'that': [25, 33, 65], 'acts': [26], 'as': [27, 163, 165], 'scaffold': [29], 'for': [30], 'protein': [31], 'complexes': [32], 'regulate': [34], 'function.': [38], 'Abnormal': [39], 'accumulation': [40, 160], 'farnesylated-progerin,': [42, 162], 'mutant': [44, 110], 'form': [45, 111], 'prelamin': [47], 'A,': [48], 'plays': [49], 'key': [51], 'role': [52], 'in': [53, 93, 149, 168], 'pathogenesis': [55], 'Hutchinson-Gilford': [58], 'progeria': [59], 'syndrome': [60], '(HGPS),': [61], 'devastating': [63], 'disorder': [64], 'causes': [66], 'death': [68], 'affected': [70], 'children': [71], 'at': [72], 'an': [73], 'average': [74], 'age': [75], '13.5': [77], 'years,': [78], 'predominantly': [79], 'from': [80], 'premature': [81], 'atherosclerosis': [82], 'myocardial': [84], 'infarction': [85], 'or': [86], 'stroke.': [87], 'Remarkably,': [88], 'progerin': [89], 'is': [90], 'also': [91], 'present': [92], 'normal': [94], 'cells': [95], 'appears': [97], 'to': [98], 'progressively': [99], 'accumulate': [100], 'during': [101], 'aging': [102], 'non-HGPS': [104], 'cells.': [105], 'Therefore,': [106], 'understanding': [107], 'how': [108], 'this': [109, 125], 'provokes': [115], 'HGPS': [116], 'may': [117], 'shed': [118], 'significant': [119], 'insight': [120], 'into': [121, 131], 'physiological': [122], 'aging.': [123], 'In': [124], 'review,': [126], 'we': [127], 'discuss': [128], 'recent': [129], 'advances': [130], 'pathogenic': [133], 'mechanisms': [134], 'underlying': [135], 'HGPS,': [136], 'main': [138], 'murine': [139], 'models': [140, 153], 'disease,': [143], 'therapeutic': [146], 'strategies': [147], 'developed': [148], 'cellular': [150], 'animal': [152], 'with': [154], 'aim': [156], 'reducing': [158], 'well': [164], 'their': [166], 'use': [167], 'clinical': [169], 'trials': [170], 'HGPS.': [172]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2317718274', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2025-01-02T13:24:54.871446', 'created_date': '2016-06-24'}