Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4221022264', 'doi': 'https://doi.org/10.3390/cells11050865', 'title': 'Mechanisms of A-Type Lamin Targeting to Nuclear Ruptures Are Disrupted in LMNA- and BANF1-Associated Progerias', 'display_name': 'Mechanisms of A-Type Lamin Targeting to Nuclear Ruptures Are Disrupted in LMNA- and BANF1-Associated Progerias', 'publication_year': 2022, 'publication_date': '2022-03-02', 'ids': {'openalex': 'https://openalex.org/W4221022264', 'doi': 'https://doi.org/10.3390/cells11050865', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35269487'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/cells11050865', 'pdf_url': 'https://www.mdpi.com/2073-4409/11/5/865/pdf?version=1646296626', 'source': {'id': 'https://openalex.org/S2736626452', 'display_name': 'Cells', 'issn_l': '2073-4409', 'issn': ['2073-4409'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/2073-4409/11/5/865/pdf?version=1646296626', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5041040692', 'display_name': 'Rhiannon M. Sears', 'orcid': 'https://orcid.org/0000-0002-5171-5036'}, 'institutions': [{'id': 'https://openalex.org/I4210095855', 'display_name': 'Sanford Research', 'ror': 'https://ror.org/00sfn8y78', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1305840828', 'https://openalex.org/I4210095855']}, {'id': 'https://openalex.org/I189957204', 'display_name': 'University of South Dakota', 'ror': 'https://ror.org/0043h8f16', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I189957204']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rhiannon M. Sears', 'raw_affiliation_strings': ['Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA', 'Enabling Technologies Group, Sanford Research, Sioux Falls, SD 57104, USA'], 'affiliations': [{'raw_affiliation_string': 'Enabling Technologies Group, Sanford Research, Sioux Falls, SD 57104, USA', 'institution_ids': ['https://openalex.org/I4210095855']}, {'raw_affiliation_string': 'Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA', 'institution_ids': ['https://openalex.org/I189957204']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028008104', 'display_name': 'Kyle J. Roux', 'orcid': 'https://orcid.org/0000-0001-7530-5528'}, 'institutions': [{'id': 'https://openalex.org/I4210095855', 'display_name': 'Sanford Research', 'ror': 'https://ror.org/00sfn8y78', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1305840828', 'https://openalex.org/I4210095855']}, {'id': 'https://openalex.org/I189957204', 'display_name': 'University of South Dakota', 'ror': 'https://ror.org/0043h8f16', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I189957204']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Kyle J. Roux', 'raw_affiliation_strings': ['Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57104, USA', 'Enabling Technologies Group, Sanford Research, Sioux Falls, SD 57104, USA'], 'affiliations': [{'raw_affiliation_string': 'Enabling Technologies Group, Sanford Research, Sioux Falls, SD 57104, USA', 'institution_ids': ['https://openalex.org/I4210095855']}, {'raw_affiliation_string': 'Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57104, USA', 'institution_ids': ['https://openalex.org/I189957204']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5028008104'], 'corresponding_institution_ids': ['https://openalex.org/I4210095855', 'https://openalex.org/I189957204'], 'apc_list': {'value': 2200, 'currency': 'CHF', 'value_usd': 2382, 'provenance': 'doaj'}, 'apc_paid': {'value': 2200, 'currency': 'CHF', 'value_usd': 2382, 'provenance': 'doaj'}, 'fwci': 1.927, 'has_fulltext': False, 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.999981, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '11', 'issue': '5', 'first_page': '865', 'last_page': '865'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11841', 'display_name': 'Nuclear Structure and Function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11841', 'display_name': 'Nuclear Structure and Function', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 0.9947, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10222', 'display_name': 'Genomics and Chromatin Dynamics', 'score': 0.974, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lmna', 'display_name': 'LMNA', 'score': 0.9904426}, {'id': 'https://openalex.org/keywords/progeria', 'display_name': 'Progeria', 'score': 0.9646723}, {'id': 'https://openalex.org/keywords/nuclear-lamina', 'display_name': 'Nuclear lamina', 'score': 0.833711}, {'id': 'https://openalex.org/keywords/inner-membrane', 'display_name': 'Inner membrane', 'score': 0.55689734}, {'id': 'https://openalex.org/keywords/premature-aging', 'display_name': 'Premature aging', 'score': 0.41251284}], 'concepts': [{'id': 'https://openalex.org/C179093185', 'wikidata': 'https://www.wikidata.org/wiki/Q424506', 'display_name': 'Lamin', 'level': 3, 'score': 0.99057037}, {'id': 'https://openalex.org/C2780654407', 'wikidata': 'https://www.wikidata.org/wiki/Q4253573', 'display_name': 'LMNA', 'level': 4, 'score': 0.9904426}, {'id': 'https://openalex.org/C2778465436', 'wikidata': 'https://www.wikidata.org/wiki/Q213098', 'display_name': 'Progeria', 'level': 3, 'score': 0.9646723}, {'id': 'https://openalex.org/C94912109', 'wikidata': 'https://www.wikidata.org/wiki/Q687194', 'display_name': 'Nuclear lamina', 'level': 5, 'score': 0.833711}, {'id': 'https://openalex.org/C65871279', 'wikidata': 'https://www.wikidata.org/wiki/Q42884945', 'display_name': 'Inner membrane', 'level': 3, 'score': 0.55689734}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5547093}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5136561}, {'id': 'https://openalex.org/C2909947164', 'wikidata': 'https://www.wikidata.org/wiki/Q6139748', 'display_name': 'Premature aging', 'level': 2, 'score': 0.41251284}, {'id': 'https://openalex.org/C29512474', 'wikidata': 'https://www.wikidata.org/wiki/Q16860021', 'display_name': 'Nuclear protein', 'level': 4, 'score': 0.36129898}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.31217915}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.20206666}, {'id': 'https://openalex.org/C2780723820', 'wikidata': 'https://www.wikidata.org/wiki/Q1934178', 'display_name': 'Nucleus', 'level': 2, 'score': 0.054488927}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D011371', 'descriptor_name': 'Progeria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007381', 'descriptor_name': 'Intermediate Filament Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007381', 'descriptor_name': 'Intermediate Filament Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D034904', 'descriptor_name': 'Lamin Type A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034904', 'descriptor_name': 'Lamin Type A', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D034904', 'descriptor_name': 'Lamin Type A', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009685', 'descriptor_name': 'Nuclear Envelope', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009685', 'descriptor_name': 'Nuclear Envelope', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011371', 'descriptor_name': 'Progeria', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011371', 'descriptor_name': 'Progeria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/cells11050865', 'pdf_url': 'https://www.mdpi.com/2073-4409/11/5/865/pdf?version=1646296626', 'source': {'id': 'https://openalex.org/S2736626452', 'display_name': 'Cells', 'issn_l': '2073-4409', 'issn': ['2073-4409'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/3dac0d482b77463e8551ffe95c60a8dd', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8909658', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2022.01.14.476371', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2022/01/18/2022.01.14.476371.full.pdf', 'source': None, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35269487', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/cells11050865', 'pdf_url': 'https://www.mdpi.com/2073-4409/11/5/865/pdf?version=1646296626', 'source': {'id': 'https://openalex.org/S2736626452', 'display_name': 'Cells', 'issn_l': '2073-4409', 'issn': ['2073-4409'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R01GM102203'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'R35GM126949'}, {'funder': 'https://openalex.org/F4320337354', 'funder_display_name': 'National Institute of General Medical Sciences', 'award_id': 'P20GM103548'}, {'funder': 'https://openalex.org/F4320337354', 'funder_display_name': 'National Institute of General Medical Sciences', 'award_id': 'P20GM103620'}], 'datasets': [], 'versions': [], 'referenced_works_count': 96, 'referenced_works': ['https://openalex.org/W1941933392', 'https://openalex.org/W1964551999', 'https://openalex.org/W1977185009', 'https://openalex.org/W1995816679', 'https://openalex.org/W1997476399', 'https://openalex.org/W2004790291', 'https://openalex.org/W2006846732', 'https://openalex.org/W2009306385', 'https://openalex.org/W2021302591', 'https://openalex.org/W2025231576', 'https://openalex.org/W2026371558', 'https://openalex.org/W2026760013', 'https://openalex.org/W2031832360', 'https://openalex.org/W2036973053', 'https://openalex.org/W2041599232', 'https://openalex.org/W2043479686', 'https://openalex.org/W2047251447', 'https://openalex.org/W2052185945', 'https://openalex.org/W2052762234', 'https://openalex.org/W2053340289', 'https://openalex.org/W2065776621', 'https://openalex.org/W2072245143', 'https://openalex.org/W2076228191', 'https://openalex.org/W2077145482', 'https://openalex.org/W2085821267', 'https://openalex.org/W2101083045', 'https://openalex.org/W2102775746', 'https://openalex.org/W2104140002', 'https://openalex.org/W2104319976', 'https://openalex.org/W2105707485', 'https://openalex.org/W2107069876', 'https://openalex.org/W2109591624', 'https://openalex.org/W2113387780', 'https://openalex.org/W2117474300', 'https://openalex.org/W2119932131', 'https://openalex.org/W2129012311', 'https://openalex.org/W2135745724', 'https://openalex.org/W2138409013', 'https://openalex.org/W2143185290', 'https://openalex.org/W2143963878', 'https://openalex.org/W2145283260', 'https://openalex.org/W2149619603', 'https://openalex.org/W2150757571', 'https://openalex.org/W2153825396', 'https://openalex.org/W2155881483', 'https://openalex.org/W2163504716', 'https://openalex.org/W2165510732', 'https://openalex.org/W2167960257', 'https://openalex.org/W2169164784', 'https://openalex.org/W2172254982', 'https://openalex.org/W2178557511', 'https://openalex.org/W2284169692', 'https://openalex.org/W2287005707', 'https://openalex.org/W2303653884', 'https://openalex.org/W2311649981', 'https://openalex.org/W2319294900', 'https://openalex.org/W2469944791', 'https://openalex.org/W2519340096', 'https://openalex.org/W2527844488', 'https://openalex.org/W2540015046', 'https://openalex.org/W2564267981', 'https://openalex.org/W2564335181', 'https://openalex.org/W2571183212', 'https://openalex.org/W2581101120', 'https://openalex.org/W2592379452', 'https://openalex.org/W2592846716', 'https://openalex.org/W2595703188', 'https://openalex.org/W2733154631', 'https://openalex.org/W2738136165', 'https://openalex.org/W2750058181', 'https://openalex.org/W2753802561', 'https://openalex.org/W2765510117', 'https://openalex.org/W2786777567', 'https://openalex.org/W2799591817', 'https://openalex.org/W2804089199', 'https://openalex.org/W2886507674', 'https://openalex.org/W2889015535', 'https://openalex.org/W2890492619', 'https://openalex.org/W2894011563', 'https://openalex.org/W2924804716', 'https://openalex.org/W2936012538', 'https://openalex.org/W2947505474', 'https://openalex.org/W2949556418', 'https://openalex.org/W2952460699', 'https://openalex.org/W2952728370', 'https://openalex.org/W2955382865', 'https://openalex.org/W2966018478', 'https://openalex.org/W2995134417', 'https://openalex.org/W3007929639', 'https://openalex.org/W3029686060', 'https://openalex.org/W3092632617', 'https://openalex.org/W3126428450', 'https://openalex.org/W3133513269', 'https://openalex.org/W3141304995', 'https://openalex.org/W3194054853', 'https://openalex.org/W3213359198'], 'related_works': ['https://openalex.org/W4221022264', 'https://openalex.org/W4206098026', 'https://openalex.org/W3176419864', 'https://openalex.org/W2317718274', 'https://openalex.org/W2255523009', 'https://openalex.org/W2119526996', 'https://openalex.org/W2066816830', 'https://openalex.org/W2052034221', 'https://openalex.org/W1554973796', 'https://openalex.org/W1484768737'], 'abstract_inverted_index': {'Mutations': [0], 'in': [1, 35, 85], 'the': [2, 57, 93, 109, 134, 171], 'genes': [3], 'LMNA': [4, 131, 186], 'and': [5, 23, 33, 43, 52, 64, 116, 181, 187], 'BANF1': [6, 188], 'can': [7], 'lead': [8], 'to': [9, 47, 83, 120, 122, 139, 143, 157, 163, 178, 194], 'accelerated': [10], 'aging': [11], 'syndromes': [12], 'called': [13], 'progeria.': [14], 'The': [15], 'protein': [16], 'products': [17], 'of': [18, 49, 76, 98, 111, 149, 185, 191], 'these': [19, 168], 'genes,': [20], 'A-type': [21, 62, 77, 99, 137, 165, 192], 'lamins': [22, 78, 104, 176, 193], 'BAF,': [24], 'respectively,': [25], 'are': [26], 'nuclear': [27, 40, 50, 123, 140, 158, 179, 195], 'envelope': [28, 41], '(NE)': [29], 'proteins': [30], 'that': [31, 69, 79, 126, 173], 'interact': [32], 'participate': [34], 'various': [36], 'cellular': [37], 'processes,': [38], 'including': [39, 56], 'rupture': [42, 51], 'repair.': [44], 'BAF': [45, 150, 154], 'localizes': [46], 'sites': [48], 'recruits': [53], 'NE-repair': [54], 'machinery,': [55], 'LEM-domain': [58], 'proteins,': [59], 'ESCRT-III': [60], 'complex,': [61], 'lamins,': [63], 'membranes.': [65], 'Here,': [66], 'we': [67], 'show': [68], 'it': [70], 'is': [71, 80, 128, 161], 'a': [72, 86], 'mobile,': [73], 'nucleoplasmic': [74], 'population': [75], 'rapidly': [81], 'recruited': [82], 'ruptures': [84, 159, 180], 'BAF-dependent': [87], 'manner': [88], 'via': [89], 'BAF’s': [90], 'association': [91], 'with': [92], 'Ig-like': [94], 'β': [95], 'fold': [96], 'domain': [97], 'lamins.': [100, 166], 'These': [101], 'initially': [102], 'mobile': [103], 'become': [105], 'progressively': [106], 'stabilized': [107], 'at': [108], 'site': [110], 'rupture.': [112], 'Farnesylated': [113], 'prelamin': [114], 'A': [115, 152], 'lamin': [117, 138], 'B1': [118], 'fail': [119], 'localize': [121], 'ruptures,': [124, 141], 'unless': [125], 'farnesylation': [127, 146], 'inhibited.': [129], 'Progeria-associated': [130], 'mutations': [132, 184], 'inhibit': [133], 'recruitment': [135, 190], 'affected': [136], 'due': [142], 'either': [144], 'permanent': [145], 'or': [147], 'inhibition': [148], 'binding.': [151], 'progeria-associated': [153], 'mutant': [155], 'targets': [156], 'but': [160], 'unable': [162], 'recruit': [164], 'Together,': [167], 'data': [169], 'reveal': [170], 'mechanisms': [172], 'determine': [174], 'how': [175, 182], 'respond': [177], 'progeric': [183], 'impair': [189], 'ruptures.': [196]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4221022264', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 4}], 'updated_date': '2024-12-27T21:31:19.372439', 'created_date': '2022-04-03'}