Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3032732757', 'doi': 'https://doi.org/10.3760/cma.j.issn.2095-0160.2017.12.003', 'title': 'Regulation of sericin on retinal endoplasmic reticulum stress specific caspase-12 dependent pathway and inhibition on apoptosis in diabetic rat', 'display_name': 'Regulation of sericin on retinal endoplasmic reticulum stress specific caspase-12 dependent pathway and inhibition on apoptosis in diabetic rat', 'publication_year': 2017, 'publication_date': '2017-12-10', 'ids': {'openalex': 'https://openalex.org/W3032732757', 'doi': 'https://doi.org/10.3760/cma.j.issn.2095-0160.2017.12.003', 'mag': '3032732757'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN115989201712/1014076.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764489546', 'display_name': 'Zhonghua shiyan yanke zazhi', 'issn_l': '2095-0160', 'issn': ['2095-0160'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 'host_organization_lineage': ['https://openalex.org/P4320800525'], 'host_organization_lineage_names': ['Chinese Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5015753506', 'display_name': 'Zhijun Dong', 'orcid': 'https://orcid.org/0000-0001-7692-5892'}, 'institutions': [{'id': 'https://openalex.org/I4210107741', 'display_name': 'Affiliated Hospital of Chengde Medical College', 'ror': 'https://ror.org/01bgds823', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107741']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhijun Dong', 'raw_affiliation_strings': ['Department of Ophthalmology, Affiliated Hospital of Chengde Medical College, Chengde 067000, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Affiliated Hospital of Chengde Medical College, Chengde 067000, China.', 'institution_ids': ['https://openalex.org/I4210107741']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101510188', 'display_name': 'Nan Yang', 'orcid': 'https://orcid.org/0000-0003-4237-4513'}, 'institutions': [{'id': 'https://openalex.org/I4210107741', 'display_name': 'Affiliated Hospital of Chengde Medical College', 'ror': 'https://ror.org/01bgds823', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107741']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Nan Yang', 'raw_affiliation_strings': ['Department of Ophthalmology, Affiliated Hospital of Chengde Medical College, Chengde 067000, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Affiliated Hospital of Chengde Medical College, Chengde 067000, China.', 'institution_ids': ['https://openalex.org/I4210107741']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100430128', 'display_name': 'Zhihong Chen', 'orcid': 'https://orcid.org/0000-0002-7359-9056'}, 'institutions': [{'id': 'https://openalex.org/I192578869', 'display_name': 'Chengde Medical University', 'ror': 'https://ror.org/02bzkv281', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I192578869']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhihong Chen', 'raw_affiliation_strings': ['Department of Human Anatomy, Chengde Medical University, Chengde 067000, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Human Anatomy, Chengde Medical University, Chengde 067000, China', 'institution_ids': ['https://openalex.org/I192578869']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101488857', 'display_name': 'Fan Yang', 'orcid': 'https://orcid.org/0000-0002-0411-7391'}, 'institutions': [{'id': 'https://openalex.org/I4210107741', 'display_name': 'Affiliated Hospital of Chengde Medical College', 'ror': 'https://ror.org/01bgds823', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107741']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fan Yang', 'raw_affiliation_strings': ['Department of Ophthalmology, Affiliated Hospital of Chengde Medical College, Chengde 067000, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Affiliated Hospital of Chengde Medical College, Chengde 067000, China.', 'institution_ids': ['https://openalex.org/I4210107741']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110689754', 'display_name': 'Hong-Fei Yu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210107741', 'display_name': 'Affiliated Hospital of Chengde Medical College', 'ror': 'https://ror.org/01bgds823', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107741']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hongfei Yu', 'raw_affiliation_strings': ['Department of Ophthalmology, Affiliated Hospital of Chengde Medical College, Chengde 067000, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Affiliated Hospital of Chengde Medical College, Chengde 067000, China.', 'institution_ids': ['https://openalex.org/I4210107741']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100294207', 'display_name': 'Weili Dong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210107741', 'display_name': 'Affiliated Hospital of Chengde Medical College', 'ror': 'https://ror.org/01bgds823', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107741']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weili Dong', 'raw_affiliation_strings': ['Department of Ophthalmology, Affiliated Hospital of Chengde Medical College, Chengde 067000, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Affiliated Hospital of Chengde Medical College, Chengde 067000, China.', 'institution_ids': ['https://openalex.org/I4210107741']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035935538', 'display_name': 'Tiemin Zhang', 'orcid': 'https://orcid.org/0000-0002-8003-984X'}, 'institutions': [{'id': 'https://openalex.org/I4210107741', 'display_name': 'Affiliated Hospital of Chengde Medical College', 'ror': 'https://ror.org/01bgds823', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210107741']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Tiemin Zhang', 'raw_affiliation_strings': ['Department of Ophthalmology, Affiliated Hospital of Chengde Medical College, Chengde 067000, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology, Affiliated Hospital of Chengde Medical College, Chengde 067000, China.', 'institution_ids': ['https://openalex.org/I4210107741']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 63}, 'biblio': {'volume': '35', 'issue': '12', 'first_page': '1067', 'last_page': '1072'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12620', 'display_name': 'Signaling Pathways in Disease', 'score': 0.9908, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12620', 'display_name': 'Signaling Pathways in Disease', 'score': 0.9908, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10086', 'display_name': "Alzheimer's disease research and treatments", 'score': 0.9825, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9798, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sericin', 'display_name': 'Sericin', 'score': 0.746914}, {'id': 'https://openalex.org/keywords/caspase-12', 'display_name': 'Caspase 12', 'score': 0.4522817}], 'concepts': [{'id': 'https://openalex.org/C206767735', 'wikidata': 'https://www.wikidata.org/wiki/Q2983186', 'display_name': 'Sericin', 'level': 3, 'score': 0.746914}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.7380045}, {'id': 'https://openalex.org/C2780827179', 'wikidata': 'https://www.wikidata.org/wiki/Q422001', 'display_name': 'Retinal', 'level': 2, 'score': 0.60969436}, {'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.55897975}, {'id': 'https://openalex.org/C2779280383', 'wikidata': 'https://www.wikidata.org/wiki/Q257331', 'display_name': 'Streptozotocin', 'level': 3, 'score': 0.5587331}, {'id': 'https://openalex.org/C196795494', 'wikidata': 'https://www.wikidata.org/wiki/Q1624817', 'display_name': 'TUNEL assay', 'level': 3, 'score': 0.5440684}, {'id': 'https://openalex.org/C139447449', 'wikidata': 'https://www.wikidata.org/wiki/Q14633900', 'display_name': 'Unfolded protein response', 'level': 3, 'score': 0.4654226}, {'id': 'https://openalex.org/C2780292996', 'wikidata': 'https://www.wikidata.org/wiki/Q18068044', 'display_name': 'Caspase 12', 'level': 5, 'score': 0.4522817}, {'id': 'https://openalex.org/C25498285', 'wikidata': 'https://www.wikidata.org/wiki/Q1981368', 'display_name': 'Neuroprotection', 'level': 2, 'score': 0.4306327}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4243654}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.40016824}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.38565096}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.37822405}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.34058756}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33133522}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.30592936}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.30577242}, {'id': 'https://openalex.org/C98424977', 'wikidata': 'https://www.wikidata.org/wiki/Q25805', 'display_name': 'Caspase', 'level': 4, 'score': 0.21117607}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.20784602}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.19652846}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15008125}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN115989201712/1014076.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764489546', 'display_name': 'Zhonghua shiyan yanke zazhi', 'issn_l': '2095-0160', 'issn': ['2095-0160'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 'host_organization_name': 'Chinese Medical Association', 'host_organization_lineage': ['https://openalex.org/P4320800525'], 'host_organization_lineage_names': ['Chinese Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.47}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3088751339', 'https://openalex.org/W3045025803', 'https://openalex.org/W3031754853', 'https://openalex.org/W3031290628', 'https://openalex.org/W3028598782', 'https://openalex.org/W2959232164', 'https://openalex.org/W2898113033', 'https://openalex.org/W2417330321', 'https://openalex.org/W2385464889', 'https://openalex.org/W2380883066', 'https://openalex.org/W2371342191', 'https://openalex.org/W2370296765', 'https://openalex.org/W2366735409', 'https://openalex.org/W2362419325', 'https://openalex.org/W2358848351', 'https://openalex.org/W2357629989', 'https://openalex.org/W2351476083', 'https://openalex.org/W2047572819', 'https://openalex.org/W1979790422', 'https://openalex.org/W1975971009'], 'abstract_inverted_index': {'Background\r\nEndoplasmic': [0], 'reticulum': [1], 'stress': [2], '(ERS)': [3], 'specific': [4, 70, 401], 'caspase-12': [5, 41, 71, 187, 325, 358, 396, 402], 'dependent': [6, 72, 403], 'pathway': [7, 73, 404], 'plays': [8], 'a': [9, 27], 'key': [10], 'role': [11], 'in': [12, 45, 74, 95, 148, 151, 190, 192, 237, 252, 260, 283, 301, 307, 329, 335, 362, 368, 399, 405], 'cell': [13, 263], 'apoptosis,': [14], 'and': [15, 86, 111, 120, 133, 156, 163, 186, 188, 194, 202, 208, 227, 230, 265, 279, 291, 295, 326, 351, 359, 397], 'apoptosis': [16, 389], 'is': [17, 26, 50], 'an': [18, 183], 'important': [19], 'characteristic': [20], 'of': [21, 59, 64, 89, 177, 210, 219, 239, 247, 255, 323, 356, 394], 'diabetic': [22, 46, 75, 77, 112, 153, 288, 309, 316, 406], 'retinal': [23, 32, 43, 65, 164, 173, 261, 387], 'neuron': [24, 33, 66, 174, 388], 'degeneration.Sericin': [25], 'potentially': [28], 'effective': [29], 'therapy': [30], 'for': [31, 91, 145, 216], 'apoptosis.However,': [34], 'whether': [35], 'sericin': [36, 60, 134], 'has': [37], 'neuroprotection': [38], 'effects': [39, 58], 'on': [40, 61], 'pathway-associated': [42], 'cells': [44, 249], 'retinopathy': [47], '(DR)': [48], 'process': [49], 'not': [51], 'unelucidated.\r\n\r\n\r\nObjective\r\nThis': [52], 'study': [53], 'was': [54, 143, 169, 272, 298], 'to': [55, 116, 171], 'investigate': [56], 'the': [57, 62, 152, 211, 217, 244, 253, 284, 296, 302, 308, 315, 319, 336, 352, 369, 392], 'inhibition': [63], 'apoptosis-associated': [67], 'with': [68, 137, 214, 243, 314], 'ERS': [69, 184, 400], 'rat.\r\n\r\n\r\nMethods\r\nThe': [76], 'models': [78, 233], 'were': [79, 106, 161, 166, 197, 234, 250, 332, 365], 'established': [80, 236], 'by': [81, 199, 224, 390], 'feeding': [82], 'high': [83], 'lipid': [84], 'foods': [85], 'intraperitoneal': [87], 'injection': [88], 'streptozotocin': [90], '3': [92], 'consecutive': [93], 'days': [94, 147], '30': [96, 241], 'SPF': [97], 'SD': [98], 'rats': [99, 105, 124, 160, 212, 254], 'aged': [100], '2-3': [101], 'months.Twenty-four': [102], 'successful': [103, 245], 'model': [104, 113, 154, 289, 317], 'randomized': [107], 'into': [108], 'sericin-treated': [109, 157, 292, 303, 337, 370], 'group': [110, 114, 155, 290, 304, 311, 338, 371], 'according': [115], 'computer': [117], 'number': [118], 'allocation,': [119], 'another': [121], '12': [122], 'matched': [123], 'served': [125], 'as': [126], 'normal': [127, 130, 138, 285], 'control': [128, 286, 310], 'group.The': [129], 'saline': [131, 139], 'solution': [132, 135, 140], 'dissolved': [136], '2.4': [141], 'g/(kg·d)': [142], 'used': [144], '35': [146], 'gavage': [149], 'method': [150], 'group,': [158, 287, 293, 318], 'respectively.The': [159, 206], 'sacrificed': [162], 'sections': [165], 'prepared.TUNEL': [167], 'staining': [168], 'employed': [170], 'detect': [172], 'apoptosis.The': [175], 'expressions': [176, 393], 'glucose': [178], 'regulated': [179], 'protein': [180, 193, 413], '78': [181], '(GRP78),': [182], 'marker,': [185], 'caspase-3': [189, 327, 360, 398], 'retinas': [191, 331, 364], 'transcription': [195, 204], 'levels': [196, 322, 355], 'detected': [198], 'Western': [200], 'blot': [201], 'reverse': [203], 'PCR,': [205], 'use': [207], 'care': [209], 'complied': [213], 'Regulations': [215], 'Administration': [218], 'Affairs': [220], 'Concerning': [221], 'Experimental': [222], 'Animals': [223], 'State': [225], 'Science': [226], 'Technology': [228], 'Commission': [229], 'ARVO': [231], 'Statement.\r\n\r\n\r\nResults\r\nDiabetic': [232], 'successfully': [235], '24': [238], 'total': [240], 'rats,': [242], 'rate': [246], '80%.Apoptotic': [248], 'found': [251], 'various': [256], 'groups,': [257], 'mostly': [258], 'locating': [259], 'ganglion': [262], 'layer': [264], 'inner': [266], 'nuclear': [267], 'layer.The': [268], 'apoptotic': [269], 'index': [270], '(AI)': [271], '0.028': [273], '4±0.002': [274], '3,': [275], '0.215': [276], '1±0.020': [277], '9': [278], '0.115': [280], '0±0.018': [281], '1': [282], 'respectively,': [294], 'AI': [297], 'significantly': [299, 333, 366], 'lower': [300], 'than': [305], 'that': [306], '(P<0.05).': [312], 'Compared': [313], 'relative': [320, 353], 'expression': [321, 354], 'GRP78,': [324, 357, 395], 'proteins': [328], 'rat': [330, 363], 'elevated': [334], '(0.523±0.029': [339], 'vs.': [340, 343, 346, 373, 376, 379], '0.924±0.039,': [341], '1.118±0.051': [342], '1.468±0.037,': [344], '0.315±0.024': [345], '0.554±0.032)': [347], '(all': [348, 381], 'at': [349, 382], 'P<0.05),': [350], 'mRNA': [361], 'reduced': [367], '(0.816±0.022': [372], '1.218±0.033,': [374], '0.216±0.023': [375], '0.407±0.012,': [377], '0.322±0.022': [378], '0.531±0.029)': [380], 'P<0.05).\r\n\r\n\r\nConclusions\r\nSericin': [383], 'can': [384], 'inhibit': [385], 'ERS-related': [386], 'down-regulating': [391], 'rats.\r\n\r\n\r\nKey': [407], 'words:': [408], '\r\nSericins/pharmacology;\xa0Diabetic': [409], 'retinopathy/physiopathology;\xa0Gene': [410], 'expression;\xa0Glucose': [411], 'regulating': [412], '78;\xa0Cysteine': [414], 'aspartate': [415, 418], 'kinase': [416, 419], '12;\xa0Cysteine': [417], '3;\xa0Rats,': [420], 'Sprague': [421], 'Dawley': [422]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3032732757', 'counts_by_year': [], 'updated_date': '2024-12-07T05:44:33.507847', 'created_date': '2020-06-05'}