Title: Apoptosis of retinal nerve cells and effects of insulin-like growth factor-I in early diabetic rats
Abstract: Early diabetic rats were randomly divided into normal control group, diabetic control group, diabetic group treated with insulin and diabetic group treated with insulin-like growth factor-I (IGF- I ). All rats were killed after 6 weeks, and the apoptotic retinal nerve cells were stained by the method of TUNEL. Expressions of Bax and Bcl-2 in the retina were studied by immunohistochemistry. IGF- I is able to increase the expression of Bcl-2, decrease the expression of Bax, and restrain the apoptosis in retinal nerve cells.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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