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['Chinese Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3032533551', 'https://openalex.org/W3030757168', 'https://openalex.org/W3030143611', 'https://openalex.org/W3030045403', 'https://openalex.org/W3029402749', 'https://openalex.org/W2825240051', 'https://openalex.org/W2393033077', 'https://openalex.org/W2391899336', 'https://openalex.org/W2391572996', 'https://openalex.org/W2384829407', 'https://openalex.org/W2378913389', 'https://openalex.org/W2375403669', 'https://openalex.org/W2364429118', 'https://openalex.org/W2358118032', 'https://openalex.org/W2356048092', 'https://openalex.org/W2355636150', 'https://openalex.org/W2353510524', 'https://openalex.org/W2351946972', 'https://openalex.org/W2349467558', 'https://openalex.org/W2347362682'], 'abstract_inverted_index': {'目的': [0], '建立去势雌干眼症动物模型并探讨干眼症模型鼠角膜上皮细胞凋亡、相关基因表达与组织损伤的关系.方法': [1], '将20只雌鼠随机分为去势雌及对照两组,每组10只.分别于手术前和手术后2、3、4、5、6个月行Schirmer试验、泪膜破裂时间(BUT)及角膜荧光素染色检测,并检测手术前后血清雌二醇水平.6个月后处死动物,取角膜进行组织病理学观察,并检测角膜上皮细胞中的bax、bcl-2等相关基因蛋白的表达.结果': [2], '术后第9': [3], 'd去势雌组血清雌二醇水平(16.34±3.15)pg/mL明显低于对照组(44.39±4.03)pg/mL(P<0.01).角膜上皮细胞中bax阳性表达的细胞数明显高于对照组(P<0.01);bcl-2阳性表达的细胞数明显低于对照组(P<0.01).结论': [4], '去势后雌鼠雌二醇水平明显低下,角膜上皮细胞中bax增加及bcl-2减少均与促进细胞凋亡有关,可能是导致组织学改变进而功能丧失引起干眼症的原因之一。': [5]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3032185873', 'counts_by_year': [], 'updated_date': '2024-09-18T10:00:24.284086', 'created_date': '2020-06-05'}