Title: Effects of Kakkonein on the Protein Expression of Bcl-2 and Bax in Rat Retina after Acute Injury
Abstract: Objective To study the effects of kakkonein on the protein expression of Bcl-2 and Bax in rat retina after acute intraocular hypertension.Methods After acute intraocular hypertension,changes in protein expression of Bcl-2 and Bax were detected by immunohistochemical method.Results In group A,there is positive expression of Bcl-2 and Bax protein.In group B,the level of positive expression of Bcl-2 and Bax protein was increased from 12h to 48h,and there is statistical difference as compared to group A(P﹤0.01).There was statistical difference on the expression of Bcl-2 and Bax between Group B and C from 12h to 48h(P﹤0.05).Conclusion The protein expression of Bcl-2 and Bax was increased in rat retina after acute intraocular hypertension and kakkonein could upregulate Bcl-2 expression and downregulate Bax expression.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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Cited By Count: 1
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