Title: Effects of estrogen on Bcl-2 and Bax expression in rat cerebellum
Abstract: Expression of Bcl-2 and Bax in cerebellum of SD rats were examined by streptavidin-peroxidase(SP) immunohistochemistry after the SD rats were ovariectomized and treated with 17β-estradiol.The expression of Bax and Bcl-2 in cerebellum cortex and bathypelagic nuclei of the ovariectomized SD rat were up-regulated and down-regulated respectively,and the expression of the 2 proteins was regulated to normal after the rats were treated with 17β-estradiol.The results showed that estrogen could prevent the cerebe-(llum) neuron from apoptosis by down-regulating the expression of Bax and up-regulating Bcl-2.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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