Publication Information

{'id': 'https://openalex.org/W3032165389', 'doi': 'https://doi.org/10.3760/cma.j.issn.1674-6554.2015.12.001', 'title': "Inhibition of Cdk5/p25 by TFP5 protects dopaminergic neurons in MPTP-induced mouse model of Parkinson's disease", 'display_name': "Inhibition of Cdk5/p25 by TFP5 protects dopaminergic neurons in MPTP-induced mouse model of Parkinson's disease", 'publication_year': 2015, 'publication_date': '2015-12-20', 'ids': {'openalex': 'https://openalex.org/W3032165389', 'doi': 'https://doi.org/10.3760/cma.j.issn.1674-6554.2015.12.001', 'mag': '3032165389'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN371468201512/866622.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3035507559', 'display_name': 'Zhonghua xingwei yixue yu naokexue zazhi', 'issn_l': '1674-6554', 'issn': ['1674-6554'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4320800525', 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'https://openalex.org/keywords/pars-compacta', 'display_name': 'Pars compacta', 'score': 0.8990835}, {'id': 'https://openalex.org/keywords/intraperitoneal-injection', 'display_name': 'Intraperitoneal injection', 'score': 0.5249693}, {'id': 'https://openalex.org/keywords/neurotoxin', 'display_name': 'Neurotoxin', 'score': 0.47288623}], 'concepts': [{'id': 'https://openalex.org/C2780938664', 'wikidata': 'https://www.wikidata.org/wiki/Q753278', 'display_name': 'Substantia nigra', 'level': 4, 'score': 0.9715247}, {'id': 'https://openalex.org/C2778674702', 'wikidata': 'https://www.wikidata.org/wiki/Q239816', 'display_name': 'MPTP', 'level': 4, 'score': 0.965279}, {'id': 'https://openalex.org/C2776773494', 'wikidata': 'https://www.wikidata.org/wiki/Q3366041', 'display_name': 'Pars compacta', 'level': 5, 'score': 0.8990835}, {'id': 'https://openalex.org/C137183658', 'wikidata': 'https://www.wikidata.org/wiki/Q461076', 'display_name': 'Dopaminergic', 'level': 3, 'score': 0.8269793}, {'id': 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'https://openalex.org/W2898310351', 'https://openalex.org/W2770582014', 'https://openalex.org/W2602518443', 'https://openalex.org/W2391756680', 'https://openalex.org/W2389484216', 'https://openalex.org/W2377780363', 'https://openalex.org/W2375803526', 'https://openalex.org/W2375768659', 'https://openalex.org/W2373139042', 'https://openalex.org/W2369008311', 'https://openalex.org/W2368139399', 'https://openalex.org/W2367876588', 'https://openalex.org/W2356687122', 'https://openalex.org/W2350516528', 'https://openalex.org/W2057598453', 'https://openalex.org/W2032134772', 'https://openalex.org/W2028580402', 'https://openalex.org/W2010129540', 'https://openalex.org/W1992367025'], 'abstract_inverted_index': {'Objective\r\nTo': [0], 'study': [1], 'the': [2, 67, 71, 89, 107, 121, 127, 147, 163, 178, 202, 206, 247], 'neuroprotective': [3, 214], 'role': [4, 215], 'of': [5, 12, 26, 29, 74, 91, 109, 124, 129, 149, 169, 171, 181, 194, 205, 228, 239, 249], 'TFP5': [6, 57, 61, 172], 'in': [7, 96, 112, 142, 152, 159, 162, 187, 231], 'a': [8], 'MPTP-induced': [9, 226], 'mouse': [10, 41], 'model': [11, 54, 164, 207, 240], "Parkinson's": [13], 'disease': [14], '(PD).\r\n\r\n\r\nMethods\r\nC57BL/6': [15], 'mice': [16, 45, 165, 208], 'were': [17, 46, 78], 'used': [18], 'as': [19, 216], 'experimental': [20], 'animals.': [21], 'Briefly,': [22], '5': [23, 49], 'consecutive': [24], 'days': [25, 119, 175], 'intraperitoneal': [27], 'injection': [28, 73, 123, 168], '25': [30], 'mg/Kg': [31], '1-methyl-4-phenyl-1,': [32], '2,': [33], '3,': [34], '6-tetrahydropyridine': [35], '(MPTP)': [36], 'was': [37, 85, 103], 'applied': [38], 'to': [39, 87, 105], 'induce': [40], 'PD': [42], 'model.': [43], 'The': [44], 'randomized': [47], 'into': [48], 'groups': [50], 'including': [51], 'control': [52], 'group,': [53, 55, 60], 'scrambled': [56], 'peptide': [58], '(Scb)': [59], 'group': [62], 'and': [63, 80, 93, 135, 200, 234], 'roscovitine': [64], 'group.': [65], 'On': [66], '7th': [68], 'day': [69], 'after': [70, 120], 'first': [72, 122], 'MPTP,': [75], 'behavior': [76], 'tests': [77], 'performed,': [79], 'then': [81], 'western': [82], 'blot': [83], 'method': [84], 'employed': [86], 'detect': [88], 'expression': [90, 128], 'p25': [92, 130], 'phosphorylated': [94, 136], 'MEF2D': [95, 137, 182], 'substantia': [97, 113, 143, 188, 232], 'nigra.Tyrosine': [98], 'hydroxylase': [99], '(TH)': [100], 'immunohistochemical': [101], 'staining': [102], 'performed': [104], 'observe': [106], 'apoptosis': [108], 'dopaminergic': [110, 150, 191, 229], 'neurons': [111, 151, 230, 257], 'nigra': [114], 'pars': [115], 'compacta': [116], '(SNpc)': [117], '28': [118], 'MPTP.\r\n\r\n\r\nResults\r\nMPTP': [125], 'increased': [126], '(0.48±0.10': [131], 'vs': [132, 139, 155, 184, 197], '0.26±0.02,': [133], 'P<0.05)': [134, 141, 186], '(0.81±0.10': [138], '0.22±0.02,': [140], 'nigra,': [144, 189, 233], 'but': [145], 'decreased': [146], 'number': [148], 'SNpc': [153, 195], '(348.67±24.40': [154], '463.29±19.61,': [156], 'P<0.05),': [157, 199], 'resulting': [158], 'motor': [160, 203, 237], 'impairment': [161, 238], '(P<0.05).': [166, 209], 'Intraperitoneal': [167], '30mg/Kg': [170], 'for': [173], '3': [174], 'effectively': [176], 'reduced': [177], 'excessive': [179], 'phosphorylation': [180], '(0.25±0.12': [183], '0.81±0.10,': [185], 'rescued': [190], 'neuron': [192], 'reduction': [193], '(422.92±8.41': [196], '348.67±24.40,': [198], 'improved': [201], 'ability': [204], 'Roscovitine': [210], 'exerted': [211], 'almost': [212], 'same': [213], 'TFP5,': [217], 'while': [218], 'Scb': [219], 'had': [220], 'no': [221], 'protective': [222], 'effect.\r\n\r\n\r\nConclusion\r\nTFP5': [223], 'can': [224], 'rescue': [225], 'damage': [227], 'thus': [235], 'improve': [236], 'mice,': [241], 'which': [242], 'may': [243], 'be': [244], 'mediated': [245], 'by': [246], 'inhibition': [248], 'Cdk5/p25': [250], 'activity.\r\n\r\n\r\nKey': [251], 'words:': [252], "\r\nParkinson's": [253], 'disease;\xa0Cyclin-dependent': [254], 'kinase': [255], '5;\xa0TFP5;\xa0Dopaminergic': [256]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3032165389', 'counts_by_year': [], 'updated_date': '2024-12-24T07:11:10.234682', 'created_date': '2020-06-05'}