Title: Comparative study of the clinical outcomes of the day 5 and day 6 high-quality frozen-thawed blastocyst transplantation
Abstract: Objective
To compare the differences of clinical outcomes in frozen-thawed blastocyst transfer (FBT) cycles between high-quality blastocysts on day 5 (D5) and on day 6 (D6).
Methods
Retrospective analysis of clinical outcomes was performed on 365 infertility patients with 387 FET cycles from January 2013 to August 2017. It was divided into four groups according to the days of the expanded blastocyst formation and the numbers of embryo transfer, there were respectively 88 cycles in double D5 blastocysts transfer group (DET5) group, 69 cycles in single D5 blastocyst transfer group (SET5) group, 129 cycles in double D6 blastocysts transfer group (DET6) group and 101 cycles in single D6 blastocyst transfer group (SET6) group.
Results
There was no significant difference in the age of patients, the infertile duration, the endometrium thickness and the proportion of embryos that survived the thawing process (P>0.05). The pregnancy rate (62.3%) and the implantation rate (62.3%) of SET5 group were significantly higher than those of SET6 group (46.5%, 46.5%) (P=0.04, P=0.04), but there was no significant difference with DET5 group and DET6 group (P>0.05). The multiple pregnancy rate of DET5 group (42.6%) and DET6 group (42.6%) was significantly higher than that of SET5 group (0.0%) and SET6 group (0.0%) (P=0.00, P=0.00).
Conclusion
In FBT cycles, selecting D5 high-quality blastocyst for SET can ensure the clinical pregnancy rate and implantation rate, and significantly reduce the multiple pregnancy rate.
Key words:
Vitrification; Blastocyst; Frozen-thawed blastocyst transfer (FBT)
Publication Year: 2018
Publication Date: 2018-07-25
Language: en
Type: article
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