Title: Impact of incubation time on pregnancy outcome of frozen-thawed blastocysts in hormone replacement therapy cycle
Abstract: Objective
To investigate the impact of incubation time on pregnancy outcome of frozen-thawed blastocysts in hormone replacement therapy (HRT) cycle and to optimize the strategy of blastocyst transplantation.
Methods
It is a retrospective cohort study, we analyzed the clinical data of 796 cases of frozen-thawed blastocysts. The cycles were divided into two groups according to the incubation time: 2-4 h group (group A, n=422) and 4-8 h group (group B, n=374). The pregnancy outcome between the two groups were compared.
Results
Group B had higher implantation rate (58.7%) and clinical pregnancy rate (72.2%) than group A (50.5%, 62.6%), the differences were statistically significant (P=0.003, P=0.004). The early abortion rate of group B (10.0%) was lower than that of group A (16.7%, P=0.025). There was no significant difference in ectopic pregnancy rate and multiple pregnancy rate between the two groups (P>0.05).
Conclusion
In the HRT cycle, proper extending the incubation time of frozen-thawed blastocysts can improve pregnancy outcomes.
Key words:
Hormone replacement therapy (HRT) cycles; Frozen-thawed blastocysts transfer; Pregnancy outcomes
Publication Year: 2018
Publication Date: 2018-12-25
Language: en
Type: article
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