Title: Effect of day 3 embryo quality on the clinical outcomes of frozen-thawed blastocyst transfer
Abstract: Objective
To investigate the relationship between day 3 (D3) embryo quality and the clinical pregnancy outcomes of frozen-thawed blastocyst transfer (FBT).
Methods
The clinical data of 1 212 frozen blastocysts transfer cycles transferred two good-quality blastocysts in our center from March 2013 to February 2017 were analyzed retrospectively. According to the morphological score of D3 cleavage embryos of transferred blastocysts, all enrolled subjects were divided into two good-quality embryo group, single good-quality group and non good-quality embryo groups, and according to the number of blastomeres on D3, they were also divided into two 8C group, single 8C group, non-8C group. The clinical outcomes of FBT were compared among groups.
Results
The embryo implantation rate (44.7%), the clinical pregnancy rate (68.3%) and the live birth rate (54.9%) in two good-quality embryo group were significantly higher than those in non good-quality embryo groups (34.4%, 55.4%, 41.1%; P=0.003, P=0.008, P=0.022). The embryo implantation rate (48.2%), the clinical pregnancy rate (71.4%) and the live birth rate (58.8%) in two 8C group were significantly higher compared with non-8C group (40.1%, 61.3%, 45.2%; P=0.002, P=0.005, P=0.002). It was also found that the multiple pregnancy rate (27.9%) in two 8C group was obviously higher than non-8C group (19.6%).
Conclusion
The clinical outcomes of FBT is closely related to the morphological score of D3 cleavage embryo, and the blastocyst derived from good-quality cleavage embryo could achieve a better clinical outcome, especially from 8C of D3. Transferring single blastocyst derived from 8C of D3 or two blastocysts derived from non good-quality cleavage embryo may lead to a higher live rate and lower multiple pregnancy rate.
Key words:
Frozen-thawed bastocyst transfer (FBT); Pregnancy rate; Live birth rate; Multiple pregnancy rate
Publication Year: 2018
Publication Date: 2018-07-25
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot