Title: Serum procalcitonin in different periods for diagnosis of early-onset of neonatal bacterial infection
Abstract: Objective
To evaluate the value of procalcitonin(PCT) in different periods for diagnosis of early-onset of neonatal bacterial infection.
Methods
One hundred and ninety-five newborns with intrauterine infection risk factors were divided into two groups: infection group(24 cases) and non-infection group(171 cases). The levels of PCT, C-reactive protein(CRP) and WBC were measured in 2 hours, 6 to 12 hours, 12 to 36 hours and more than 48 hours after birth.The sensitivity and specificity of PCT in different periods in the diagnosis of early-onset infection were analyzed.
Results
There were no significant differences in the positive rate of PCT, CRP and WBC in infection group in 2 hours after birth(P>0.05). The sensitivity and specificity for diagnosis of early-onset infection of PCT were 91.7% and 86.5% at 6 to 12 hours after birth, which were higher than those of CRP and WBC.After birth in 12 to 36 hours was the physiologic peak of PCT, so it couldn't have higher sensitivity and specificity.According to threshold of 0.5 ng/ml, 2 ng/ml, and 10 ng/ml for PCT, the sensitivity was 100%, 91.7% and 100% respectively, and the specificity was 5.8%, 53.8% and 95.9% respectively.
Conclusion
PCT in 6 to12 hours after birth, according to threshold of 2 ng/ml, can reach higher sensitivity and specificity for diagnosis of early-onset neonatal bacterial infection.
Key words:
Procalcitonin; C-reactive protein; Early-onset infection
Publication Year: 2016
Publication Date: 2016-04-20
Language: en
Type: article
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