Title: Clinical Significance of CRP and PCT Detection in the Diagnosis of Neonatal Infection Related to Premature Rupture of Membranes
Abstract: Objective To investigate the clinical significance of detection serum C reaction protein( CRP) and procalcitonin( PCT) levels in the diagnosis of neonatal bacterial infection related to premature rupture of membranes. Methods 163 cases of single full-term newborns including 113 cases of premature rupture of membranes( PROM) were chosen as observation group. The observation group based on the signs of infection in neonates was further divided into non infection group( 40 cases),local infection group( 45 cases) and systemic infection group( 28 cases),non premature rupture of membranes early broken group( control group,50 cases).The serum CRP and PCT levels at 24 h,3 and 7days after birth were detected. Results The cord blood PCT and CRP levels in systemic infection group were significantly higher than that of local infection group,non infected group and the control group( P 0. 01). The serum PCT and CRP levels in systemic infection group at 3 days after birth were higher than that at 1 day. The serum PCT and CRP levels at 7 days were decreased and lower than that of 1 and 3 days. The serum PCT levels in local infection group at 1 and 3 days after birth were slightly high,but there was no significant difference with control compared with that at 7 to 10 days after birth.Conclusion The detection of cord blood PCT content can be more reliable predictors of severe neonatal earlyonset infection,and could be used for guiding the clinical antibiotics application,evaluation of curative effect and judging of prognosis.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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