Title: Significance of procalcitonin in diagnosis of neonatal sepsis
Abstract: Objective To investigate the value of procalcitonin(PCT) in the diagnosis of neonatal sepsis.Methods Neonates aged 0-28 days were divided into three groups of A(188 cases,aged 0-3 days without neonatal infection),B1(30 cases,aged 3-28 days with neonatal sepsis) and B2(30 cases,aged 3-28 days without neonatal sepsis).Serum concentrations of PCT and C-reactive protein(CRP) were determined and blood culture and blood cell count were performed.ResultsSerum PCT peaked in 24-36 h after birth(1.27-2.94 g/L),which recovered to normal range of 0.24-0.41 μg/L 48 h later.Taking PCT≥0.68 μg/L as a diagnostic marker,the sensitivity(90.0%),specificity(93.3%),positive predict value(93.1%),negative predict value(90.3%),accuracy(91.7%) and Youden′s index(83.3%) were all higher than 80.0%,86.7%,85.7%,81.3%,83.3%,and 66.7% by CRP.Conclusion Serum PCT concentration of newborns shows a physiological peak in 3 days after birth.Serum PCT concentration is a sensitive and specific marker in the diagnosis of neonatal septicemia when PCT≥0.68 μg/L is taken as a diagnostic criterion.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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