Title: The role of blood procalcitonin and C-reaction protein of umbilical artery in prematures with early-onset infection
Abstract: Objective:To investigate the early and reliable diagnostic method and clinical significance of blood procalcitonin(PCT) and C-reaction proteion(CRP) in prematures with early-onset infection.Methods:The level of plasma PCT and CRP in umbilical artery in 52 neonates with suspected infection was respectively examined by immunoluminometric assay.The attending neonatologists from our hospital performed all care.Desigmation of infection status had to be made respectively becauce all neonates were considered at risk for,or demonstrated clinical evidence of infection.Those of us responsible for classifying the infants as critical infection(early-onset infection) vs the local infection and the uninfection were blind to the CRP and PCT values.52 neonates were divided into two groups:critical infection group(early-onset infection,n=28) and control group(local infection and uninfection,n=24).Results:The early-onset infection in prematures was associated with significant increase in the concentrations of CRP and PCT at the time of birth,with significant difference(P0.001).The increase of the concentration of PCT in umbilical artery was positively correlated with the change of CRP level,the coefficient of linear correlation was 0.88.The sensitivity and specificity of PCT were 96.4% and 95.8% respectively,both were greater than those of CRP(75.0% and 91.6%).Conclusion:PCT can be used as an early diagnostic marker for the early-onset infection in prematures,especially severe infection.The sensitivity and specificity of PCT are greater than those of CRP.The method is non-injured.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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