Title: Ki-67 expression in T1 primary breast cancer tissue and its relationship with Her-2 and ER
Abstract: Objective To study the expression of Ki-67 in T1 primary breast cancer tissue and its relationship with Her-2 and ER,evaluate the prognosis of early breast cancer.Method s Sixty cases of women T1 primary breast cancer tissues of 60 female cases from January 2008 to June 2011 were selected.The expressions of Ki-67 were detected by immunohistochemieal method and the relationships between Ki-67 and clinical-pathological fcatures,Her-2 and ER were analysed.Results The expression of Ki-67 in T1 primary breast cancer was 55% among the 60 patients.The expression of Ki-67 was not related with the clinical-pathological type of breast cancer and menopause (P>0.05).The expression of Ki-67 in group with lymph node metastasis was higer than in group without lymph node metastasis(P =0.047 ,P <0.05).The expression of Ki-67 in Her-2positive group was higher than Her-2 negative group (P= 0.021,P<0.05),and the expression of Ki-67 in ER positive group was lower than that of ER negative group (P = 0.037,P < 0.05).Conclusions The expression of Ki-67 in T1 primary breast cancer indicates the possibility of lymph node metastasis,and its positive correlation with Her-2 positive expression,ER negative expression indicates poor prognosis.
Key words:
Ki-67; T1 primary breast cancer; Her-2; ER
Publication Year: 2011
Publication Date: 2011-08-15
Language: en
Type: article
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