Title: Expressions and clinical significances of ER,PR,HER-2 and Ki67 in human medullary carcinoma of the breast
Abstract: Objective:To investigate the expressions and clinical significances of estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor-2(HER-2) and cell proliferative nuclear antigen Ki67 in human medullary carcinoma of the breast.Methods:The pathological data of 43 cases of medullary breast carcinoma(MBC) were collected.The expressions of ER,PR,HER-2 and Ki67 in carcinoma tissues in 43 cases were detected by immunohistochemical S-P method.Another 120 cases of invasive ductal carcinoma(IDC) of the breast were chosen as the controls.Results:The positive expression rates of ER,PR,HER-2 and Ki67 in MBC tissues were 8/43(18.75%),11/43(25.58%),14/43(32.56%),7/43(16.28%),respectively;meanwhile,the positive rates in IDC were 25/120(20.83%),33/120(27.50%),49/120(40.83%),42/120(35.00%),respectively.The positive rate of Ki67 in IDC was significantly higher than that in MBC(P0.05).The positive expression of Ki67 was associated with tumor volume and lymph node metastasis(P0.05),but not correlated with the age and clinical stage.There was a positive relationship between the expression of Ki67 and HER-2(r=0.447,P0.05) and there was no relationship between the expression of Ki67 and PR and PR(r=0.113 and r=1.129,P 0.05).Conclusions:The expression of Ki67 is correlated with the genesis,development of breast cancer,which can be considered as a biological indicator in MBC.It will be useful for the prognosis through detecting the expression of Ki67 combined with ER,PR and HER-2.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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