Title: Clinical significance of BRCA1 and Ki-67 expression in breast cancer
Abstract: Objective To investigate the clinicopathologic features and prognostic significance of BRCA1 and Ki-67 expression in breast cancer.Methods The expression levels of BRCA1 and Ki-67 were assayed by immunohistochemistry in 194 cases of breast cancer tissues.The correlations of BRCA1 and Ki-67 expression with patients' clinicopathologic features were also analysed.Results Low expression of BRCA1 was detected in the lymph node metastasis group,ER/PR negative group,and HER-2 positive group in 194 patients with breast cancer (P < 0.05),as well as in the triple negative breast cancer (TNBC) group compared to non-TNBC group (P <0.05).High expression of Ki-67 was detected in patients with higher histological grade,negative ER/PR,and positive HER-2 (P < 0.05).Furthermore,negative correlation was found between the expression of BRCA1 and Ki-67 (P < 0.05).The combination of low expression of BRCAl and high expression of Ki-67 was mostly found in the patients with postmenopausal,lower histological grade,lymph node metastasis,negative ER/PR and positive HER-2 (P < 0.05).However,there was no significant difference between TNBC and non-TNBC.Conclusion Joint detection of BRCA1 and Ki-67 might play an important role in predicting clinical outcomes of breast cancer,especially BRCA1 may be one of prognostic factors in TNBC.
Key words:
Breast neoplasms; BRCA1; Ki-67; Immunohistochemistry
Publication Year: 2014
Publication Date: 2014-01-28
Language: en
Type: article
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Cited By Count: 1
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