Publication Information

{'id': 'https://openalex.org/W3029115840', 'doi': 'https://doi.org/10.3760/cma.j.issn.1007-1245.2020.05.002', 'title': 'Protective effect and mechanisms of Neurotropin on apoptotic C17.2 neural stem cells induced by H2O2', 'display_name': 'Protective effect and mechanisms of Neurotropin on apoptotic C17.2 neural stem cells induced by H2O2', 'publication_year': 2020, 'publication_date': '2020-03-01', 'ids': {'openalex': 'https://openalex.org/W3029115840', 'doi': 'https://doi.org/10.3760/cma.j.issn.1007-1245.2020.05.002', 'mag': '3029115840'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN441417202005/1188410.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306546010', 'display_name': '国际医药卫生导报', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100421454', 'display_name': 'Yi Li', 'orcid': 'https://orcid.org/0000-0002-2092-4505'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210097354', 'display_name': 'Sun Yat-sen Memorial Hospital', 'ror': 'https://ror.org/01px77p81', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097354']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yi Li', 'raw_affiliation_strings': ['Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510210, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510210, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210097354']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037563519', 'display_name': 'Yuqiu Zheng', 'orcid': 'https://orcid.org/0000-0002-3194-7956'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210096354', 'display_name': 'The Seventh Affiliated Hospital of Sun Yat-sen University', 'ror': 'https://ror.org/00rfd5b88', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210096354']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yuqiu Zheng', 'raw_affiliation_strings': ['Department of Neurology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China.', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210096354']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015932761', 'display_name': 'Yachun Hu', 'orcid': None}, 'institutions': [], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yachun Hu', 'raw_affiliation_strings': ['Department of EEG, Guangzhou Hui’ai Hospital, Guangzhou 510370, China'], 'affiliations': [{'raw_affiliation_string': 'Department of EEG, Guangzhou Hui’ai Hospital, Guangzhou 510370, China', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078136185', 'display_name': 'Shengnuo Fan', 'orcid': 'https://orcid.org/0000-0003-1372-8474'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210097354', 'display_name': 'Sun Yat-sen Memorial Hospital', 'ror': 'https://ror.org/01px77p81', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097354']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shengnuo Fan', 'raw_affiliation_strings': ['Department of Rehabilitation Medicine; Sun Yat-Sen Memorial Hospital; Sun Yat-Sen University; Guangzhou 510120 China'], 'affiliations': [{'raw_affiliation_string': 'Department of Rehabilitation Medicine; Sun Yat-Sen Memorial Hospital; Sun Yat-Sen University; Guangzhou 510120 China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210097354']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103504233', 'display_name': 'Ying Xiong', 'orcid': 'https://orcid.org/0009-0002-3581-2845'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210097354', 'display_name': 'Sun Yat-sen Memorial Hospital', 'ror': 'https://ror.org/01px77p81', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097354']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ying Xiong', 'raw_affiliation_strings': ['Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510210, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510210, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210097354']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100670797', 'display_name': 'Songhua Xiao', 'orcid': 'https://orcid.org/0000-0001-5537-012X'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210097354', 'display_name': 'Sun Yat-sen Memorial Hospital', 'ror': 'https://ror.org/01px77p81', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097354']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Songhua Xiao', 'raw_affiliation_strings': ['Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510210, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510210, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210097354']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100361720', 'display_name': 'Jun Liu', 'orcid': 'https://orcid.org/0000-0001-9202-5878'}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210097354', 'display_name': 'Sun Yat-sen Memorial Hospital', 'ror': 'https://ror.org/01px77p81', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097354']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jun Liu', 'raw_affiliation_strings': ['Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510210, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510210, China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210097354']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 60}, 'biblio': {'volume': '26', 'issue': '05', 'first_page': '600', 'last_page': '605'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.8595, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.8595, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12963', 'display_name': 'Anesthesia and Neurotoxicity Research', 'score': 0.7503, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12626', 'display_name': 'Cancer, Stress, Anesthesia, and Immune Response', 'score': 0.7444, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.7359008}], 'concepts': [{'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.77316153}, {'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.7359008}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.6522641}, {'id': 'https://openalex.org/C136834591', 'wikidata': 'https://www.wikidata.org/wiki/Q2944097', 'display_name': 'Neural stem cell', 'level': 3, 'score': 0.6467208}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.5729902}, {'id': 'https://openalex.org/C25498285', 'wikidata': 'https://www.wikidata.org/wiki/Q1981368', 'display_name': 'Neuroprotection', 'level': 2, 'score': 0.54356515}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.5167398}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.49206275}, {'id': 'https://openalex.org/C533411734', 'wikidata': 'https://www.wikidata.org/wiki/Q171877', 'display_name': 'Hydrogen peroxide', 'level': 2, 'score': 0.46632057}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.46113837}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.42802396}, {'id': 'https://openalex.org/C105580179', 'wikidata': 'https://www.wikidata.org/wiki/Q188928', 'display_name': 'Messenger RNA', 'level': 3, 'score': 0.41621423}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4111596}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.22698724}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.17485648}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.066595644}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN441417202005/1188410.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306546010', 'display_name': '国际医药卫生导报', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3174588729', 'https://openalex.org/W3141371042', 'https://openalex.org/W3042150507', 'https://openalex.org/W3032811247', 'https://openalex.org/W3029007310', 'https://openalex.org/W2982420234', 'https://openalex.org/W2890191291', 'https://openalex.org/W2883330664', 'https://openalex.org/W2805441371', 'https://openalex.org/W2415161303', 'https://openalex.org/W2390805229', 'https://openalex.org/W2388964529', 'https://openalex.org/W2382216185', 'https://openalex.org/W2372147879', 'https://openalex.org/W2372099562', 'https://openalex.org/W2372047276', 'https://openalex.org/W2363296601', 'https://openalex.org/W2357930182', 'https://openalex.org/W2355799963', 'https://openalex.org/W2349027170'], 'abstract_inverted_index': {'Objective\r\nTo': [0], 'investigate': [1], 'the': [2, 31, 69, 72, 86, 89, 93, 100, 109, 124, 132, 149, 158, 167, 172, 181], 'protective': [3], 'effect': [4, 189], 'and': [5, 105, 108, 156, 163, 165, 207], 'its': [6], 'possible': [7], 'mechanisms': [8], 'of': [9, 34, 41, 52, 62, 71, 74, 88, 95, 103, 112, 151, 161, 170], 'Neurotropin': [10, 140], '(NTP)': [11, 141], 'on': [12, 190], 'hydrogen': [13, 193], 'peroxide': [14, 194], '(H2O2)-induced': [15], 'apoptosis': [16, 133], 'in': [17, 195], 'C17.2': [18, 63, 196], 'neural': [19, 64, 197, 211], 'stem': [20, 65, 198, 212], 'cells.\r\n\r\n\r\nMethod\r\ns': [21], 'Cell': [22], 'counting': [23], 'kit-8': [24], '(CCK-8)': [25], 'assay': [26], 'was': [27], 'used': [28], 'to': [29, 137, 204], 'test': [30], 'cell': [32, 146], 'viability': [33, 87], 'each': [35], 'group.': [36], 'The': [37, 49, 60, 115], 'intracellular': [38, 152], 'ROS': [39], 'levels': [40, 51, 150], 'cells': [42, 66, 90], 'were': [43, 56, 118, 175], 'observed': [44], 'under': [45], 'a': [46, 186], 'fluorescence': [47], 'microscope.': [48], 'mRNA': [50, 101, 110, 159, 168], 'p53,': [53, 205], 'Bax,': [54, 164, 206], 'Bcl-2': [55, 113], 'detected': [57], 'by': [58, 135, 192], 'qPCR.\r\n\r\n\r\nResult\r\ns': [59], 'vitality': [61], 'decreased': [67], 'with': [68, 78, 123, 139, 180], 'increase': [70, 145], 'concentration': [73], 'H2O2.': [75], 'After': [76], 'treated': [77], '1': [79], '000': [80], 'μM': [81], 'H2O2': [82, 136], 'for': [83, 142], '2': [84], 'h,': [85, 144], 'significantly': [91, 120, 130, 177], 'decreased,': [92], 'production': [94], 'reactive': [96, 153], 'oxygen': [97, 154], 'species': [98], 'increased,': [99, 107], 'expression': [102, 111, 160, 169], 'p53': [104, 162], 'Bax': [106], 'decreased.': [114], 'above': [116, 173], 'results': [117], 'statistically': [119, 176], 'different': [121, 178], 'compared': [122, 179], 'control': [125, 182], 'group': [126, 183], '(P<0.05).': [127], 'It': [128], 'can': [129], 'improve': [131], 'induced': [134], 'pretreat': [138], '24': [143], 'viability,': [147], 'decrease': [148], 'species,': [155], 'inhibit': [157], 'up-regulate': [166], 'Bcl-2,': [171], 'indicators': [174], '(P<0.05).\r\n\r\n\r\nConclusion\r\nNeurotropin': [184], 'demonstrated': [185], 'potential': [187], 'neuroprotective': [188], 'apoptosis-induced': [191], 'cells,': [199], 'which': [200], 'might': [201], 'be': [202], 'related': [203], 'Bcl-2.\r\n\r\n\r\nKey': [208], 'words:': [209], '\r\nNeurotropin;\xa0C17.2': [210], 'cells;\xa0Apoptosis': [213]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3029115840', 'counts_by_year': [], 'updated_date': '2024-12-30T05:14:16.462069', 'created_date': '2020-06-05'}