Publication Information

{'id': 'https://openalex.org/W3032811247', 'doi': 'https://doi.org/10.3760/cma.j.issn.1007-1245.2017.06.001', 'title': 'Neuroprotective effect of Neurotropin on H2O2-induced injury in pheochromocytoma cells', 'display_name': 'Neuroprotective effect of Neurotropin on H2O2-induced injury in pheochromocytoma cells', 'publication_year': 2017, 'publication_date': '2017-03-15', 'ids': {'openalex': 'https://openalex.org/W3032811247', 'doi': 'https://doi.org/10.3760/cma.j.issn.1007-1245.2017.06.001', 'mag': '3032811247'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN441417201706/991333.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306546010', 'display_name': '国际医药卫生导报', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102257218', 'display_name': 'Wenli Fang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}, {'id': 'https://openalex.org/I4210097354', 'display_name': 'Sun Yat-sen Memorial Hospital', 'ror': 'https://ror.org/01px77p81', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097354']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Wenli Fang', 'raw_affiliation_strings': ['Department of Neurology Sun Yat‐sen Memorial Hospital, Sun Yat‐sen University Guangzhou 510120 China'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurology Sun Yat‐sen Memorial Hospital, Sun Yat‐sen University Guangzhou 510120 China', 'institution_ids': ['https://openalex.org/I157773358', 'https://openalex.org/I4210097354']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078136185', 'display_name': 'Shengnuo Fan', 'orcid': 'https://orcid.org/0000-0003-1372-8474'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Shengnuo Fan', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073969669', 'display_name': 'Wang Liao', 'orcid': 'https://orcid.org/0000-0002-6187-0443'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Wang Liao', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037563519', 'display_name': 'Yuqiu Zheng', 'orcid': 'https://orcid.org/0000-0002-3194-7956'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yuqiu Zheng', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112372986', 'display_name': 'Shaowei Liao', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Shaowei Liao', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 63}, 'biblio': {'volume': '27', 'issue': '06', 'first_page': '771', 'last_page': '785'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12626', 'display_name': 'Cancer, Stress, Anesthesia, and Immune Response', 'score': 0.6685, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12626', 'display_name': 'Cancer, Stress, Anesthesia, and Immune Response', 'score': 0.6685, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/viability-assay', 'display_name': 'Viability assay', 'score': 0.7222298}], 'concepts': [{'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.7614659}, {'id': 'https://openalex.org/C53227056', 'wikidata': 'https://www.wikidata.org/wiki/Q189152', 'display_name': 'Viability assay', 'level': 3, 'score': 0.7222298}, {'id': 'https://openalex.org/C25498285', 'wikidata': 'https://www.wikidata.org/wiki/Q1981368', 'display_name': 'Neuroprotection', 'level': 2, 'score': 0.69370866}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.688334}, {'id': 'https://openalex.org/C48349386', 'wikidata': 'https://www.wikidata.org/wiki/Q424361', 'display_name': 'Reactive oxygen species', 'level': 2, 'score': 0.6348301}, {'id': 'https://openalex.org/C553184892', 'wikidata': 'https://www.wikidata.org/wiki/Q1141429', 'display_name': 'Flow cytometry', 'level': 2, 'score': 0.61799026}, {'id': 'https://openalex.org/C181911157', 'wikidata': 'https://www.wikidata.org/wiki/Q389844', 'display_name': 'Membrane potential', 'level': 2, 'score': 0.575834}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.52537954}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.49430633}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.47342256}, {'id': 'https://openalex.org/C169274487', 'wikidata': 'https://www.wikidata.org/wiki/Q840211', 'display_name': 'Fluorescence microscope', 'level': 3, 'score': 0.41177}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.40083963}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3839562}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.2997896}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2170909}, {'id': 'https://openalex.org/C91881484', 'wikidata': 'https://www.wikidata.org/wiki/Q191807', 'display_name': 'Fluorescence', 'level': 2, 'score': 0.08749899}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN441417201706/991333.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306546010', 'display_name': '国际医药卫生导报', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3195540821', 'https://openalex.org/W3193082173', 'https://openalex.org/W3141371042', 'https://openalex.org/W3098973560', 'https://openalex.org/W3042150507', 'https://openalex.org/W3029115840', 'https://openalex.org/W3013414737', 'https://openalex.org/W2890191291', 'https://openalex.org/W2883330664', 'https://openalex.org/W2470257204', 'https://openalex.org/W2415809534', 'https://openalex.org/W2415161303', 'https://openalex.org/W2392836181', 'https://openalex.org/W2388964529', 'https://openalex.org/W2372047276', 'https://openalex.org/W2368397312', 'https://openalex.org/W2361880467', 'https://openalex.org/W2352884306', 'https://openalex.org/W2225695586', 'https://openalex.org/W2074046054'], 'abstract_inverted_index': {'Objective\r\nTo': [0], 'investigate': [1], 'the': [2, 25, 29, 36, 42, 64, 84, 89, 109, 118, 121, 124, 133, 137, 148, 158, 175, 184, 191, 194, 197, 203, 212, 217, 230, 233, 236, 240, 245], 'effect': [3], 'of': [4, 38, 44, 52, 67, 86, 92, 103, 120, 128, 140, 151, 165, 181, 186, 193, 205, 232, 239, 247], 'Neurotropin': [5, 166], 'on': [6], 'H2O2-induced': [7, 218], 'oxidative': [8, 40], 'stress': [9, 259], 'injury': [10, 219], 'in': [11, 132, 220], 'pheochromocytoma': [12], '(PC12)': [13], 'cells': [14, 39, 94], 'and': [15, 50, 63, 70, 76, 113, 116, 142, 178, 188, 201, 207, 251], 'its': [16], 'potential': [17], 'mechanism.\r\n\r\n\r\nMethods\r\nThe': [18], 'CCK-8': [19], 'assay': [20], 'was': [21, 32, 58, 95, 153], 'applied': [22], 'to': [23, 34, 228], 'measure': [24], 'cell': [26, 110, 176], 'viability': [27, 177], 'while': [28, 147], 'flow': [30], 'cytometry': [31], 'used': [33], 'detect': [35], 'occurrence': [37], 'injury,': [41], 'level': [43, 119, 231], 'intracellular': [45], 'reactive': [46], 'oxygen': [47], 'species': [48], '(ROS)': [49], 'changes': [51], 'mitochondrial': [53, 134, 198, 241], 'membrane': [54, 135, 199, 242, 261], 'potential.': [55], 'The': [56, 98], 'ROS': [57, 122], 'observed': [59], 'by': [60, 74], 'fluorescence': [61, 126], 'microscope,': [62], 'mRNA': [65, 138, 149, 179], 'expressions': [66, 139, 180, 204], 'Caspase-3,': [68], 'Bax,': [69], 'Bcl-2': [71, 152], 'were': [72, 130, 144], 'detected': [73], 'immunofluorescence': [75], 'quantitative': [77], 'real': [78], 'time': [79], 'polymerase': [80], 'chain': [81], 'reaction': [82], '(qRT-PCR).\r\n\r\n\r\nResults\r\nAs': [83], 'increase': [85], 'H2O2': [87, 104, 213], 'concentration,': [88], 'survival': [90], 'rate': [91], 'PC12': [93, 221], 'decreased': [96, 131, 154, 183], 'gradually.': [97], 'treatment': [99], 'with': [100, 157, 163, 211], '450': [101], 'μM': [102], 'for': [105, 169], '24': [106], 'h': [107], 'induced': [108], 'viability,': [111], 'apoptosis': [112, 187], 'necrosis': [114], 'significantly': [115, 145], 'increased': [117, 196], 'evidently;': [123], 'red/green': [125], 'ratios': [127], 'JC-1': [129], 'potential;': [136], 'Bax': [141, 206], 'Caspase-3': [143, 208], 'increased,': [146], 'expression': [150, 246, 250], '(P<0.05,': [155, 209], 'compared': [156, 210], 'control': [159], 'group).': [160], 'In': [161], 'contrary,': [162], 'pretreatment': [164], '(0.01': [167], 'UN/ml)': [168], '12': [170], 'h,': [171], 'it': [172], 'obviously': [173], 'enhanced': [174], 'Bc1-2,': [182], 'rates': [185], 'necrosis,': [189], 'lessened': [190], 'accumulation': [192], 'ROS,': [195, 234], 'potential,': [200, 243], 'inhibited': [202], 'group).\r\n\r\n\r\nConclusion\r\nNeurotropin': [214], 'can': [215], 'inhibit': [216], 'cells.': [222], 'Its': [223], 'neuroprotective': [224], 'role': [225], 'may': [226], 'relate': [227], 'decreasing': [229], 'maintaining': [235], 'high': [237], 'energy': [238], 'inhibiting': [244], 'pro-apoptotic': [248], 'gene': [249, 254], 'promoting': [252], 'anti-apoptotic': [253], 'expression.\r\n\r\n\r\nKey': [255], 'words:': [256], '\r\nNeurotropin;\xa0PC12': [257], 'cells;\xa0Oxidative': [258], 'injury;\xa0Mitochondrial': [260], 'potential;\xa0Apoptosis': [262]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3032811247', 'counts_by_year': [], 'updated_date': '2024-12-15T18:25:29.828802', 'created_date': '2020-06-05'}