Title: Expression of RAB5A and MMP-9 in colorectal cancer and their correlation
Abstract: Objective To investigate the expression of RAB5A and MMP-9 in colorectal cancer and their correlation.Methods By using immunohistochemical technique,the expression of RAB5A and MMP-9 was detected in 46 colorectalcarcinomas,tumor-adjacent colorectal carcinoma tissues and23 nor- mal tissues.Results In 46 eases of colorectal cancer,the positive expression rate of RAB5A protein which was located in cytoplasm and on the membrane of the cells was 100%(46/46)and that of MMP- 9 which was located in cytoplasm 73.91%(34/46)respectively.The expression of RAB5A and MMP-9 in colorectal cancer was high in the patients with lymph node metastasis,late Duke's stage and low differ- entiation(P<0.05).The expression of MMP-9 in colorectal cancer was high in the patients with deep invasion(P<0.05).The expression of RAB5A and MMP-9 had no relationship with gender,age and tu- mor site(P>0.05).There was a positive correlation betweenthe expression of RAB5A and MMP-9 (P<0.05,r=0.434).Conclusion Expression of RAB5A and MMP-9 might be used a reference indi- cator for evaluating malignancy and metastasis of colorectal cancer.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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