Title: Clinical observation of low molecular weight heparin in the treatment of unstable angina
Abstract: Objective To compare curative effects of low molecular weight heparin and ordinary heparin in the treatment of unstable angina. Methods Forty-three patients with unstable angina corresponding to diagnosis criteria were divided into treatment group and control group on the basis of conventional treatment.On the basis of conventional treatment,at first the control group was given intravenous ordinary heparin 5000U,then ordinary dose was maintained in dose of 1000U/h and continuously adjusted.When activate part of prothrombin time(aPTT) reached up 1.5~2 times of the normal reference value, maintained for seven days. The treatment group was given routine treatment and low molecular weight heparin calcium 4100U subcutaneously Q12h,for 7 days. The number of anginal attack, duration, ECG changes, coagulation and hemorrhage index before and after treatment were observed. Results The anginal attack freguency and duration, ischemia load in two groups significantly reduced(P0.01),but after treatment, there was significant difference between treatment group and control group(P0.05).The change of coagulation index in the treatment group was no obvious(P0.05),but the change of coagulation index in the control group was statistically significant(P0.01). Conclusion The efficacy of ordinary heparin and low molecular weight heparin is similar, but low molecular weight heparin is more obvious effective, simple and safe with low side effects.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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