Title: Expression of MMP-9,TIMP-1 and infection of bacterial L-forms in ovarian neoplasms and its clinical significance
Abstract: Objective To study the expression of MMP-9,TIMP-1 and infection of bacterial L-froms in ovarian neoplasms and to discuss the clinical significance.Methods Hybridization in situ and immunohistochemical staining was used to detect the expression of MMP-9,TIMP-1 mRNA and protein in 120 cases of ovarian tumors.Gram's straining was used to examine the positive rate of bacterial L-forms in these tissues.Results The positive rates of MMP-9,TIMP-1 mRNA and protein expression was higher in malignant tumors than that in benign ones(P0.005).The expression of MMP-9 and TIMP-1 were higher in clinical stage Ⅰ,Ⅱ than that in stage Ⅲ,Ⅳ,and which was increased with the grade(P0.005 to P0.01).The expression of these two marks were higher in patients with lymph node involvement and ascites than those without that(P0.005 to P0.05).The positive expression of TIMP-1 was opposite to MMP-9(P0.005~P0.05).The positive rate of bacterial L-froms was no high in malignant tumors than that in benign ones(P0.05),but it was increased with clinical stage and pathological grade(P0.005).The expression of L-froms was higher in patients with lymph node involvement and ascites than those without that(P0.005).Conclusions In ovarian neoplasma,the abnormal expression of MMP-9,TIMP-1 and positive rate of bacterial L-forms have obvious relationship with clinical stage,pathological grade,lymph node involvement and ascites.Bacterial L-forms maybe one of the inductive factors of the occurrence of tumor.The expression of MMP-9 and TIMP-1 with cooperative of L-forms is likely to promote a faster invasion and metastasis of ovarian carcinomas.Therefore,to study the infection of bacterial L-forms has an important clinical significance.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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