Title: Expression and clinical significance of COX-2,Ki-67 and L-type bacterial infection in ovarian tumors
Abstract: Objective To study the expression of cox-2 and ki-67 acceptor and infection of bacteria L-forms in ovarian neoplasm and discuss their clinical correlation. Method Immunohistochemical staining,Hybridization in situ and Gram's stain were used to detect the expression of cox-2 and ki-67 protein and mRNA in 120 cases of ovarian carcinoma and examine the positive rate of bacteria L-forms in these tissues.The major clinical data and parameter of the pathological grades were compared in 97 cases of ovarian papillary carcinoma and 23 cases of ovarian papillary epithelioma. Result The positive rate of expression of the cox-2 and ki-67 protein and mRNA was obviously higher in malignant tumors than that in benign(P0.01).The positive rate of examination of infection of bacteria L-forms had no significantly difference in between ovarian benign tumors and malignancy(P0.05).The positive rate of expression of the cox-2 and ki-67protein,mRNA and examination rate of infection of bacteria L-forms had significantly difference with regard to the clinical stage,pathological grades,celiac lymph node metastasis and ascites in ovarian papillary carcinoma(P0.01).The positive rate of the expression of cox-2 and ki-67 protein and mRNA was apparently higher in patients with infection of bacteria L-forms than that without infection.The two groups had significant difference with each other(P0.01). Conclusion cox-2 and ki-67protein and mRNA have certain abnormal expression in ovarian tumors.These expression are in positive correlation with clinical stage,pathological grade,infiltration and metastasis.Infection of bacteria L-forms could be one of the inductive factors of the occurrence of tumors.Mutation and abnormal expression of cox-2 and ki-67 mRNA and infection of bacteria L-forms may have a concurrent action during the course of the occurrence and development of tumors.To investigate the relationship between ovarian carcinoma and infection of bacteria L-forms is important for clinical practice.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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