Title: Changes and their significance of urinary monocyte chemoattractant protein-1 excretion in type 2 diabetics
Abstract: Objective To observe the changes of the urinary MCP-1 excretion,and analyse its relationship with albuminuria in T2DM.Methods 20 normal controls(group A,N=20) and 56 diabetics were enrolled in this study,with diabetics were divided into 3 groups according to(ACR: mg·g-1·Cr-1): normoalbuminuria group(group B,N=21),micro-albuminuria group(group C,N=20),and macroalbuminuria group(group D,N=17).Urinary MCP-1 were measured by enzyme-linked immunosorbent assay(ELISA).Results There were no significant differences between normal control group and group B,C and D in age,sex,and body mass index;Compared with group A,the UMCP-1/urinary creatinine(Ucr) in group B increased significantly(P0.01),and increased further in group C and group D(P0.01);UMCP-1/Ucr was positively related with ACR,HbA1c,serum TC and TG.Conclusions UMCP-1 excretion is increased in type 2 diabetics,which is related to the degree of diabetic nephropathy.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot