Title: Changes of MCP-1 and its relationship with proteinuria in IgA nephropathy in children
Abstract: Objective:To study the change of monocyte chemoattractant protein-1(MCP-1) in serum and urinethe and its relationship with proteinuria in IgA nephropathy in children. Methods:From January 2008 to October 2011,33 children with IgA nephropathy were divided into macroalbuminuria group(1.5 g)(n=22) and microalbuminuria group(≤ 1.5 g)(n=11) according to 24 h urinary protein,while 50 cases of healthy children at the same period were chosen as control group.Enzyme-linked immunosorbent assay(ELISA) was employed to test the level of serum and urine MCP-1 of the three groups,meanwhile,24 hours urinary protein,serum creatinine,urine β2-microglobulin levels and renal function of all the patients were measured. Results:The levels of MCP-1 in macroalbuminuria group,microalbuminuria group and the control group were respectively(138.8±58.5) pg / ml,(76.4±36.2) pg / ml,(22.6±12.1) pg / ml in urine,and(23.9±5.1) pg / ml,(19.6±4.2) pg / ml,(17.6±2.5) pg / ml in serum.MCP-1 levels in urine were statistically significantly different(P0.05),but there was no statistically significant difference(P0.05). Conclusion:MCP-1 in children with IgA nephropathy may play an important role in renal dyfunction,and urinary MCP-1 can be used as a complementary indicator of renal function for IgA nephropathy in children.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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