Title: Clinical efficacy of zinc in the adjunctive treatment of infantile rotavirus enteritis
Abstract: Objective To observe the clinical efficacy of zinc in the treatment of infantile rotavirus enteritis. Methods One hundred and forty patients admitted from Aug. 2010 to Oct. 2012 were randomly divided into the treatment group (n=76) and the control group (n=64). The control group was given ribavirin+cimetidine+smectite therapeutic regimen and symptomatic treatment, based on which the treatment group was added with zinc gluconate or zinc glycyrrhetate granules orally. After treatment for 72 h, the clinical efficacy of the two groups was compared, and serum zinc level, immunoglobulin level were checked and compared after treatment for 14 d. Results ① After treatment for 14 d, serum zinc and IgG, IgA, IgM all increased, and zinc, IgG, IgA levels of the treatment group were significantly higher than those of the control group (P0.05). ② After treatment, diarrhea duration of the treatment group [(6.21± 1.5) d] was significantly lower than that of the control group [(7.14±1.8) d], P0.05. ③ After treatment for 72 h, the overall effective rare and markedly effective rate of the treatment group were both significantly higher than those of the control group (P0.05). Conclusion For infantile rotavirus enteritis, zinc supplementation based on regular therapy can improve children’s immune function, shorten diarrhea course, and improve the treatment efficiency.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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