Title: Clinical efficacy of adenosine methionine in treatment of cholestatic hepatitis patients
Abstract: [Objective]To observe the efficacy and adverse events of s-adenosy-L-methione(SAMe)S-adenosyl methionine in treatment of cholestatic hepatitis patients.[Methods]Sixty-eight patients with cholestasis hepatitis were randomly divided into the treatment group(38cases)and the control group(30cases).The two groups were given conventional treatment,treatment group were added with SAMe injection 1.0g/d intravenous drip,control group were treated with Kuhuang injection 30ml/d intravenous drip.The regimen lasted for four weeks.Before and after treatment,the symptoms and signs,biochemical indexes(TBil,DBil,ALT,AST, -GT,TBA),curative effect and adverse reaction of the two groups were observed.[Results]After treatment,total bilirubin(TBil),direct bilirubin(DBil),gamma glutamyltranspeptidase(-GT)and total bile acid(TBA)in the treatment group decreased significantly than those in the control group(P0.05 or P0.01).The improvement rates of cinereous stool and skin pruritus in treatment group were significantly higher than those in control group(P0.05 or P0.01).The total effective rates of treatment group was 84.2%,which was higher than 60.0% of control group(P0.05).The two groups showed no serious adverse reactions.[Conclusion]SAMe has good clinical efficacy and safety for the treatment of cholestatic hepatitis patients.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot