Title: Significance of TGF-β1、TβRII and P38 in the occurrence and development for gastric carcinoma
Abstract: Objective To study the expression of TGF-β1,TGF-βⅡand p38 in the different stages of gastric carcinoma and evaluate their significance in pathogenisis and development of gastric carcinoma.Methods Immunohistochemical SP method was used to examine the expression TGF-β1,TβRⅡand P38 in 60 cases of gastric carcinoma,15 cases of gastric adenoma,and 30 cases of normal gastric tissues.Results Compared with those in normal gastric tissues,the expression levels of TGF-β1 and P38 increased in the gastric carcinoma,while that of TβRⅡdecreased.The expression of TGF-β1 correlated positively with that of P38 in the gastric carcinoma,there exist a negative correlation of the positive expression between TGF-β1 and TβRⅡ(P0.05),and there also exist a negative correlation of the positive expression between TβRⅡ and P38(P0.05).The expression of TGF-β1 and P38 is related with invasion depth,clinical stage and lymphatic metastases.The expression of TβRⅡ is related with histological differentiation, invasion depth, clinical stage and lymphatic metastases. Conclusion The expression of TGF-β1,TβRⅡ and P38 is correlated with the development,biologic behavior and prognosis of gastric carcinoma.Determination of TGF-β1、TβRⅡand P38 is very helpful in early diagnosis and evaluating the prognosis of gastric carcinoma.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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