Title: The study of cyclooxygenase-2 expression in gastric Carcinoma
Abstract: Objective To explore expression of cyclooxygenase-2(COX-2) and its relationship with invasion and metastasis of gastric carcinoma.Methods The streptavidin-Peroxidase immunohistochemistry was used to determine the expression of cyclooxygenase-2 in 57 tissues of gastric cancer.Results The rates of cyclooxygenase-2 expression in tissues of gastric carcinoma and normal stomach were 85.2% and 28.1%,the level of cyclooxygenase-2 expression had no correlation with histology differentiation of gastric carcinoma(P0.05).The level of cyclooxygenase-2 expression had significant correlations with lymph node metastasis,deep invaded and TNM stage of gastric carcinoma(P0.01).Conclusion The level of Cox-2 expression is significantly related to the invasion and metastasis of gastric carcinoma.The level of Cox-2 expression is one of the important biologic character of gastric carcinoma.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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