Title: The Study of Relationship Between the Expression of P~(27kip1) and the Clinical Biological Behavior in Gastric Carcinoma Tissues
Abstract: Objective To study the expression of P27kip1 in gastric carcinoma,and the correlations between the expression and the clinical biological behavior of gastric carcinoma.Methods To examining the expression of P27kip1 in normal gastric mucosa and gastric carcinoma by immunohistochemistry method(SP method).Results The expression of P27kip1 in gastric carcinoma is lower significantly than that in normal gastric mucosa(P0.01),In the gastric carcinoma,the expression of P27kip1 correlate with the differentiation,invasive depth,lymph node metastasis,PTNM stages and 5-year survival rate(P0.01 or P0.05),but not with patient's sex,age and the tumor location,size,gross type(P0.05).Conclusion The abnormal expression of P27kip1 participate in the genesis and development of gastric carcinoma.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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