Title: HPV infection and expression of NF-κB and their correlation with ovarian carcinoma
Abstract: Objective To investigate the infection of HPV and expression of nuclear factor kappaB(NF-κB) in epithelial ovarian tumor and to study their correlation.Methods In situ hybridization and immunohistochemical method were applied to detect HPV infection in tumor cells,while immunohistochemical method was employed to detect the expressions of NF-κB protein .Result The HPV infection rates of malignant ovarian tumor and benign ovarian tumor were 35.56% and 5.56% respectively through in situ hybridization detection,while the positive expression rates of HPV protein were 31.11% and 0.00% respectively through immunohistochemical detection.The HPV infection in malignant tumors was significantly higher than that in benign tumors(P0.05).HPV infection was correlated with histological grading,but the positive expression rates of HPV infection with in situ hybridization and immunohistochemical method showed no significant difference(P0.05);The positive expression rates of p65 in malignant epithelial tumors and ovarian benign epithelial tumors were 68.89% and 27.78% respectively.The NF-κB p65 protein expression in malignant tumors was significantly higher than that in benign tumors(P0.05).The expression of NF-κB/p65 protein had a close relation with histological differentiation,clinical stages and CA125(P0.05).Positive HPV expression was strongly correlated with NF-κB expression(P0.05).Conclusions The infection of HPV and up regulated expression of NF-κB may be related to the development of epithelial ovarian carcinoma.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot