Title: Carcinoma showing thymus-like element of the thyroid:a clinicopathological observation
Abstract: Objective To investigate the clinical-pathological features of carcinoma showing thymus-like differentiation(CASTLE) of the thyroid. Methods This rare case of CASTLE was studied for histomorphology and immunohistochemical features with review of the related literature. Results Macroscopically,the tumor showed a solid gray-white mass and was separated into lobules by fibrous tissues,mature lymphocytes and plasma cells infiltration in the fibrous septum.The tumor cells were polygonal to spindle in shape,vesicular nucleus,distinct nucleoli and scattered squamous pattern of differentiation.The tumor stained positively for CD5 and CD117. Conclusion Carcinoma showing thymus-like differentiation is a rare malignancy that occurs in the soft tissues of the neck or in the thyroid gland.It needs to be distinguished from undifferentiated thyroid carcinoma,squamous cell thyroid carcinoma,lymphoepithelioma-like carcinoma.Immunohistochemical staining for CD5 and CD117 is helpful in confirming the diagnosis.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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Cited By Count: 2
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