Title: RELATIONSHIP AMONG INTRATUMOR MICROVESSEL DENSITY,CLINICOPATHOLOGICAL FEATURES AND CELL PROLIFERATION IN HUMAN ENDOMETRIAL ADENOCARCINOMA
Abstract: Objective To investigate the expression of CD34 of microvessel density(MVD) and the relationship among MVD,clinicopathological features and cell proliferation in patients with endometrial adenocarcinoma. Methods The expressions of CD34 and Ki-67 in 20 cases of normal endometrium and 70 cases of endometrial adenocarcinoma were detected by immunohistochemical EnviSion method. Results MVD value in the endometrial adenocarcinoma was significantly higher than that in the normal endometrium(t=12.67,P0.001).There was no relationship between the value of MVD and patient's age,pathological grade(t=1.673,F=2.09,P0.05),but it was related to clinical stage,myometrial invasion and lymph node metastasis(F=5.77;t=5.650,6.445;P0.01,0.001).Expression of Ki-67 was positively correlated with MVD(t=2.522,P0.05). Conclusion MVD is associated with the growth,invasion and metastasis of endometrial adenocarcinoma.Combination detection of MVD and Ki-67 can be used as a parameter to judge the biological behavior and prognosis of endometrial adenocarcinoma.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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Cited By Count: 1
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