Title: Relationship between Microvessel Density and MMP-9 Expression in Endometrioid Adenocarcinoma and Its Significance
Abstract: Objective To investigate the relationship between microvessel density (MVD) and the expres sion of matrix metalloproteingase-9 (MMP-9) in endometrioid adenocarcinoma and its biological significance. Methods Immunohistochemistry was used to detect the expression of MMP-9 and MVD in 74 cases with endometrioid adenocarci noma and 22 cases with proliferative endometrium. The significance and relationship between MMP-9 and MVD market by CD-34 in different lesions were analyzed. Results The positive expression rate of MMP-9 and MVD in endometrioi adenocarcinoma was higher than that of proliferative endometrium(P 0. 05 ). Overexpression of MMP-9 and MVD in en dometrioid adenocarcinoma was related to its depth of invasion and differentiation degree ( P 0. 05 ). Conclusion MMP-9 and MVD are closely associated with the biological behavior of endometrioid adenocarcinoma; MMP-9 can pro mote angiogenesis.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
Access and Citation
Cited By Count: 1
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot