Title: Expressions and clinical significance of CXCR4 and HIF-1α in breast cancer cells
Abstract: OBJECTIVE:To investigate the relationship between the expressions of chemokine receptor CXCR4 and hypoxia-inducible factor-1α(HIF-1α)and lymph node metastasis in human breast cancer.METHODS:Immuohistochemistry was used to detect the expressions of CXCR4 and HIF-1α in 48 cases of human breast cancer.The relationship between CXCR4 and HIF-1α expressions and the clinicpathological diameters was statistically analyzed.RESULTS:The positive rate of CXCR4 expression with lymph node metastasis was higher than that without lymph node metastasis(75% vs 40.6%,P=0.025).The positive rate of HIF-1α expression with lymph node metastasis was higher than that without lymph node metastasis(75% vs 37.5%,P=0.014).The positive expression of CXCR4 was consistent with the positive expression of HIF-1α,and the expression levels of CXCR4 and HIF-1α were closely correlated with lymph node metastasis,but not with the age,tumor size and histological type.CONCLUSION:CXCR4 and HIF-1α were expressed in human breast cancer,and may play important roles in lymphatic metastasis of human breast cancer.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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