Title: Study on the expression of p38 protein in human breast carcinoma tissue
Abstract: Objective To determine the expression of p38 protein in human breast carcinomas and to explore its relation to development of breast carcinomas.Methods Expressions of p38 protein in 60 breast cancer cases were determined by S-P immunohistochemistry.Results Of 38 cases of breast carcinoma with lymph nodes metastasis,there were 29 cases of positive expression of p38 protein(positive rate 76.3%);of 22 cases without lymph nodes metastasis,there were 9 cases with positive expression of p38 protein(positive rate 40.9%)(P0.01). The positive rate of p-p38 in patients who had lymph nodes metastasis was 68.4%,and the positive rate in patients who had no metastasis was 36.4%(P0.05).Conclusions P38 signal transduction pathway could play a key role in invasion and metastasis of breast cancer,expression of which be related to clinical staging of breast carcinoma.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot