Title: The expression correlation of Aurora-A and EGFR in lung adenocarcinoma
Abstract: Objective This study was designed to investigate the expression of Aurora-A(Aur-A) and epidermal growth factor receptor(EGFR), and the clinicopathological significance of Aur-A and EGFR in patients with resected lung adenocarcinoma.Methods The protein expression of Aur-A and EGFR in 105 lung adenocarcinoma tissues were assessed by Immunohistochemistry(IHC), and their correlations with clinicopathological features were statistically analyzed. Results The over-expression rate of Aur-A was 71.4%(75 / 105). A positive correlation between Aur-A over-expression rate and ascending pathological stages was observed(P0.05). In addition, the expression of Aur-A had a positive correlation with EGFR(P0.001). The co-expression of Aur-A and EGFR related to node metastasis status(P0.05). Conclusion The expression of Aur-A could be considered as a biological marker to estimate the progression of lung adenocarcinoma. Combine detection of EGFR may help to judge the metastasis of lung adenocarcinoma.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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