Title: Expressions and significances of Survivin and vascular endothelial growth factor in salivary adenoid cystic carcinoma
Abstract: Objective To investigate the expression of Survivin and its relationship with expression of vascular endothelial growth factor(VEGF) in adenoid cystic carcinoma(ACC)of salivary gland.Methods The expression of Survivin and VEGF were detected by Immunohistochemically ultrasensitive staining(S-P) in 38 cases of ACC tissues.Results The expression rates of Survivin and VEGF in the 38 cases of ACC were 71.1%and 63.2%,respectively.The positive rate of Survivin was strongly associated with pathological group and clinical grade(P0.05),but was not related to site,tumor size and lymph node metastasis.The positive rate of VEGF was strongly associated with clinical grade.pathological group and lymph node metastasis(P0.05),but was not related to site,tumor size.The expression of Survivin was correlated with that of VEGF(r=0.667,P0.05).Conclusion Survivin and VEGF may participate in the onset and development of ACC.Detection of Survivin and VEGF protein may be valuable to further understand the biological behavior of ACC.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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