Title: Expression of survivin and vascular endothelial growth factor in thyroid carcinoma and its significance
Abstract: Objective To investigate the expression of survivin (an apoptosis inhibitor) in thyroid carcinoma and its relationship with vascular endothelial growth factor (VEGF) expression. Methods Sixty-eight cases of thyroid carcinoma, 12 cases of thyroid adenoma and 10 cases of normal thyroid tissue were involved. Immunohistochemistry (SABC method) was used to detect the expression of survivin, caspase-3 and VEGF, and then their relationship with the major clinicalpathologicalparametersofthyroidcarcinoma was analysed. Results No survivin was expressedinnormalthyroidtissue,butsurvivinwasweakly expressed in thyroid adenoma (16.7%) and strongly expressed in thyroid carcinoma (57.4%); caspase-3 was obviously expressed in three kinds of tissue (70.0%, 75.0%, 69.1%), and VEGF was expressed in 75.0% of thyroid carcinoma and 41.7% of thyroid adenoma. In thyroid carcinoma, survivin expression had no correlation with caspase-3 expression, but significant positive correlation existed between surviving and VEGF (r=0.302,P0.05) according to histological classification, clinical staging and lymph node metastasis. Conclusions Survivin is specifically expressed in thyroid carcinoma and is probably involved in the pathogenesis of thyroid carcinoma via inhibiting apoptosis and promoting angiogenesis with the synergetic effect of VEGF.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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