Title: Neogenetic microvessel density and invasion/metastasis of primary hepatocellular carcinoma
Abstract: Objectives:To study the relationship between tumor MVD and invasion/metastasis of primary hepatocellular carcinoma(HCC). Methods:Paraffin embedded specimens from tumor tissue in 30 patients with primary hepatocellular carcinoma and liver tissue in 20 ones who had undergone radical hepatectomy were studied. Angiogenesis was assessed by the microvessel density(MVD) method using LSAB immunohistochemical staining. The mean of MVD were counted in the five areas of highest density under 400 times magnification microscopy. Results:①The MVD in HCC was higher than that in the non tumorous liver tissue( P 0.01).②Metastatic tumor MVD or noncapsulated tumor MVD were higher than those without metastasis or well encapsulated tumors( P 0.05).③There was no significant difference between large HCC(diameter 5 cm) MVD and small HCC(diameter≤5 cm) MVD( P 0.05). Conclusions:MVD are highly correlated with invasion/metastasis of primary HCC, which may serve as a parameter for determining tumor biology, metastasis and prognosis, also in supervising and treating HCC.
Publication Year: 2000
Publication Date: 2000-01-01
Language: en
Type: article
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