Title: The Significance of MVD in Metastasis of Primary Hepatocellular Carcinoma
Abstract: Objective: To evaluate the relationship between density of microvessels (MVD) and invasion, metastasis of primary hepatocellular carcinoma (HCC). Methods: Paraffin-embedded specimens of 30 primary HCC and 20 normal hepatic tissue adjacent to carcinoma were studied by LSAB immunohistochemical staining. The expression of VEGF and MVD were detected.The average number of MVD was counted microscopically in 5 fields under 400×high power. Results: (1) The MVD in HCC was significantly higher than that in normal hepatic tissue adjacent to carcinoma (P0.01). (2) The MVD in tumors with metastasis or without intact capsule was significantly higher than those without metastasis or with intact capsule (P0.05). (3)There was no significant difference in MVD between large (diameter5cm) and small (diameter≤5cm) HCC (P0.05) Conclusion: The MVD of primary HCC is closely related with its invasion and metastasis, which may serve as a parameter to determine the growth,metastasis and prognosis of HCC, and provide a new idea for supervising and treatment of HCC.
Publication Year: 2001
Publication Date: 2001-01-01
Language: en
Type: article
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