Title: Expression levels of p53 and MVD correlate with clinical significance in hepatocellular carcinoma
Abstract: Objective: To study the relationship between the expression of p53 and MVD and the clinical pathogical characteristics in human hepatocellular carcinoma. Methods: The expressions of p53 and CD34 were examined by S-P immunohistochemical technique in 50 cases of human hepatocellular carcinoma. Results: p53 was located in the cell nucleus of tumor cells and CD34 manly in the cell cytoplasm of vessel endothlial cells. MVD was significantly hiher in p53-positive HCC than in p53-negative HCC (P0.05). p53 expression and MVD were closely corrlated to tumor size, number, differentiation, emboli in the vein and capsule (P0.05). They were also corrlated with prognosis of HCC. The mean tumor-free survial of MVD≥148 was 12 months while that of MVD148 was 46 months (P0.05). Follow-up showed that postoperative surival time was markedly lower in HCC patients with positive expression of p53. Conclusions: p53 expression of significantly associates with MVD. The expression of p53 and MVD can be the predictors for the bilogical behavior and prognosis.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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