Title: Efficacy of thrombolysis by intravenous recombinant tissue plasminogen activator in hyperacute cerebral infarction
Abstract: Objective: To evaluate the efficacy of thrombolysis by intravenous rt-PA in hyperacute cerebral infarction(ACI).Methods: ACI patients(n=60) within 3 h after the onset of stroke were enrolled in the trial.They were randomly divided into rt-PA(n=30) and control groups(n=30).rt-PA was administered in a dose of 0.9 mg·kg-1(maximum dose 50 mg) intravenously.Dalteparin(5 000 IU) was subcutaneously injected,twice a day for 7 days,in control group.The NIHSS scores were evaluated before and 2 h,24 h,14 d,3 months after treatments.At 3 months,BI scale,the incidence of secondary intracranial hemorrhage(sICH) and the mortality were calculated to assess the efficacy and safety.Results: The NIHSS scores at each time point and BI scales at 3 months were significantly improved in rt-PA group as compared with control group(P0.05 and 0.01).The incidence of sICH and the mortality at 3 months were not significantly different between the two groups(P0.05).Conclusion: Administration of rt-PA within 3 h of onset is safe and effective in ACI patients.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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