Title: Clinical Analysis of Intravenous Thrombolysis Therapies in Acute Cerebral Infarction with Different Dosage of Reconstructive Tissue Plasminogen Activator(rt-PA)
Abstract: Objective FDA recomanded 0.9mg/kg IV rt-PA in thrombolysis treatment for acute ischemic stroke. The trials about IV rt-PA in china have chosen some different dose. To analyze the suitable dosage of rt-PA in Chinese we compared 0.9mg/kg IV rt-PA with 0.6-0.8mg/kg(50mg/person) IV rt-PA. Methods 30 patients were randomly assigned in our study. The NIHSS were from 2 to 26, the stroke onset time is 0.5 to 6 hours, without contraindications to thrombolytic therapy(China cerebrovascular disease guide contraindication of thrombolysis). The patients were randomly divided into Group A and B, Group A with rt-PA 50mg/person, Group B with rt-PA 0.9mg/kg. To compare between two groups the number of patients with a decrease of 4 or more points on the National Institutes of Health Stroke Scale (NIHSS) at 24 hours and day 14. The intracerebral hemorrhage rate and mortality were also be compared. Results The two groups were well matched on baseline characteristics, including NIHSS (mean of 10.17for both). NIHSS improvement rate of group B at day 14 is signifcient better than group A (86.67% vs 53.3%, P0.05).The intracerebral hemorrhage rate of two groups were both 6%. The mortality at 14 days in Group A were higher than Group B(26.67% vs 20%, P=0.67). Conclusion This study found signifi cant benefi t on 14 days in patients treated by 0.9mg/kg IV rt-PA than (0.6-0.8)mg/kg(50mg/person) IV rt-PA after stroke onset. Risk of intracerebral hemorrhage and mortality was not increased in 0.9mg/kg IV rt-PA. 0.9mg/kg IV rt-PA was suitable for Chinese in thrombolysis treatment for acute ischemic stroke.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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