Title: Effect of rt-PA on S100B Protein in Patients with Acute Cerebral Infarction
Abstract: Objective:To investigate the efficacy and safety of recombinant tissue-type plasminogen activator (rt-PA) in acute cerebral infarction (ACI),and the effect to S100B Protein.Method:64 ACI patients (stroke onset within 4.5 h) were randomized into rt-PA and control groups.The control group were treated with conventional therapy,and the rt-PA group with additional rt-PA besides conventional therapy.The S100B Protein level were measured in 64 ACI patients on admission and 3,7,14 days after treatment and in 10 healthy patients (normal group).The Chinese Stroke Scale (CSS) and the Barthel Index (BI) were used to evaluate the neurological functions before and 90 days after treatment.Result:On admission, the S100B Protein level in rt-PA and control groups were significantly higher than in normal group (P0.01),there was no significant difference between the rt-PA and control group (P0.05),the S100B Protein level was significantly lower 3,7,14 days after treatment in both groups (P0.01),and it was significantly lower in rt-PA group than in control group(P0.01).CSS scores and BI of the rt-PA group and the control group showed no significant difference before treatment(P0.05) and were significantly different after treatment (P0.01).The bleeding complication rate was no significant different in two groups(P0.05).Conclusion:Intravenous rt-PA thrombolysis within 4.5 h from onset can significantly reduce S100B Protein level and is effective and safe in ACI patients.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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