Title: Expression and significance of Oct-4 in oral squamous cell carcinomas
Abstract: Objective:To study the expression of Oct-4 in oral squamous cell cancer(OSCC)tissue,demonstrate its significant in the formation of OSCC and relationship with cancer stem cells.Method:In 41 oral squamous cell carcinoma tissues and 5 normal mucosa tissues,the expression of Oct-4 was examined by using immunohistochemistry and reverse transcription-PCR.Result:In contrast to negative expression in 5 normal oral mucosa tissues,41 of OSCC cases are all showed positive expression of Oct-4.OSCC showed the expressions of Oct-4 mRNA while the normal mucosa tissues not.Conclusion:Since Oct-4 was key transcription factor of stem cells,the expression of Oct-4 showed there might exist OSCC stem cells.This has significance applications for the final isolation and identification of OSCC stem cells.The findings of our research showed the new target for carcinogenesis initiation of OSCC,this has significance applications for the prevention and treatment of OSCC.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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